Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 5/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | CDK7 | P50613 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25242417 | 0.83 | POLB (0.40) | POLBGAAAKR1C3TYK2IGF1R | |
| SCHEMBL31247590 | 0.80 | MAPK10 (0.43) | POLBTYK2MAP4K1IGF1RCDK7 | |
| SCHEMBL25285692 | 0.78 | TYK2 (0.59) | POLBGAATYK2TNNI3KJAK1 | |
| SCHEMBL25293421 | 0.78 | GAA (0.53) | POLBGAATYK2TNNI3KMAPT | |
| SCHEMBL25243670 | 0.75 | POLB (0.48) | POLBGAAAKR1C3TYK2TNNI3K | |
| SCHEMBL25242779 | 0.75 | POLB (0.48) | POLBGAAAKR1C3TYK2TNNI3K | |
| SCHEMBL25243819 | 0.75 | TYK2 (0.66) | POLBGAAAKR1C3TYK2TNNI3K | |
| SCHEMBL25243614 | 0.74 | TYK2 (0.52) | POLBGAAAKR1C3TYK2TNNI3K | |
| SCHEMBL25287175 | 0.74 | POLB (0.49) | POLBGAAAKR1C3TYK2TNNI3K | |
| SCHEMBL25288885 | 0.73 | POLB (0.48) | POLBGAAAKR1C3TYK2TNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |