Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | C1R | P00736 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25293421 | 0.85 | GAA (0.53) | POLBGAATP53TNNI3KAURKA | |
| SCHEMBL25242554 | 0.78 | POLB (0.47) | POLBGAATP53TNNI3KMAPK10 | |
| SCHEMBL25283961 | 0.78 | EGFR (0.48) | POLBGAATP53TNNI3KMAPK10 | |
| SCHEMBL25242828 | 0.77 | LRRK2 (0.47) | POLBGAATHRBAKR1C3ABL1 | |
| SCHEMBL25288626 | 0.76 | TYK2 (0.45) | POLBGAATHRBTYK2 | |
| SCHEMBL25244650 | 0.74 | TYK2 (0.59) | POLBGAAMAPTTYK2 | |
| SCHEMBL25285692 | 0.74 | TYK2 (0.59) | POLBGAATNNI3KTYK2 | |
| SCHEMBL25293423 | 0.74 | POLB (0.51) | POLBGAATP53TNNI3KAKR1C3 | |
| SCHEMBL25288885 | 0.74 | POLB (0.48) | POLBGAATP53TNNI3KAKR1C3 | |
| SCHEMBL25284382 | 0.74 | HPGD (0.51) | GAAMAPTMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |