Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 7/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31270804 | 0.89 | KDM4E (0.42) | GRIN2BBRD4ADORA2BADORA2A | |
| SCHEMBL25301779 | 0.89 | KDM4E (0.42) | GRIN2BBRD4ADORA2BADORA2A | |
| SCHEMBL29030555 | 0.89 | NPC1 (0.37) | GRIN2BADORA2ANPY5RMEN1KMT2A | |
| SCHEMBL25299136 | 0.79 | GPR119 (0.43) | ADORA2BADORA2A | |
| SCHEMBL25254475 | 0.79 | GRIN2B (0.55) | GRIN2BMEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL31025948 | 0.79 | GRIN2B (0.55) | GRIN2BMEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL29030594 | 0.79 | GRIN2B (0.44) | GRIN2BADORA2BADORA2ACYP3A4CYP2D6 | |
| SCHEMBL25257180 | 0.77 | MAPK8 (0.36) | ADORA2BADORA2AMEN1KMT2A | |
| SCHEMBL29030581 | 0.75 | GRIN2B (0.39) | GRIN2BADORA2BCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL25301684 | 0.75 | NPC1 (0.38) | ADORA2BADORA2AL3MBTL1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125121-A1 | TRICYCLIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2023-07-06 | — | — | WO | disclosed |