Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | ESRRG | P62508 | 1/20 | 0.47 |
| ▸ | NME4 | O00746 | 1/20 | 0.46 |
| ▸ | GCDH | Q92947 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | PTAFR | P25105 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25263437 | 0.90 | MAPT (0.52) | MAPTTP53ESRRGNME4GCDH | |
| SCHEMBL25262291 | 0.87 | ABL1 (0.49) | MAPTTP53ESRRGCA1CA2 | |
| SCHEMBL25305249 | 0.85 | MAPT (0.65) | MAPTTP53ESRRGNME4GCDH | |
| SCHEMBL25306854 | 0.84 | MAPT (0.57) | MAPTTP53ESRRGNME4GCDH | |
| SCHEMBL25309254 | 0.82 | MAPT (0.53) | MAPTTP53ESRRGMEN1KMT2A | |
| SCHEMBL25308935 | 0.80 | MAPT (0.67) | MAPTTP53ESRRGNME4GCDH | |
| SCHEMBL25309227 | 0.77 | MAPT (0.58) | MAPTTP53MCHR1NPC1CYP1A2 | |
| SCHEMBL25308786 | 0.77 | MAPT (0.57) | MAPTTP53PRKD1NPC1RAB9A | |
| SCHEMBL25307575 | 0.77 | MAPT (0.54) | MAPTTP53NME4GCDHSIRT5 | |
| SCHEMBL25308366 | 0.77 | RAB9A (0.55) | MAPTTP53ESRRGNME4GCDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023130540-A1 | PYRAZOL BENZAMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 苏州大学 | 2023-07-13 | — | — | WO | disclosed |
| WO-2023130540-A1 | PYRAZOL BENZAMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 苏州大学 | 2023-07-13 | — | — | WO | disclosed |
| CN-114394934-B | Pyrazole benzamide compound as well as preparation method and application thereof | 苏州大学 | 2023-06-13 | — | — | CN | disclosed |
| CN-114394934-A | Pyrazole benzamide compound and preparation method and application thereof | 苏州大学 | 2022-04-26 | — | — | CN | disclosed |