Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | RAF1 | P04049 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 4/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25262291 | 0.91 | ABL1 (0.49) | MAPTTP53RAF1ABL1BCR | |
| SCHEMBL25309227 | 0.91 | MAPT (0.58) | MAPTTP53RAF1NPC1RAB9A | |
| SCHEMBL25306725 | 0.90 | MAPT (0.53) | MAPTTP53RAF1RAB9AHDAC3 | |
| SCHEMBL25856271 | 0.84 | RAF1 (0.56) | MAPTTP53RAF1BRAFROCK1 | |
| SCHEMBL29033904 | 0.81 | RAF1 (0.57) | RAF1BRAFPRKD1 | |
| SCHEMBL25307234 | 0.77 | MAPT (0.48) | MAPTTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25306854 | 0.77 | MAPT (0.57) | MAPTTP53NPC1RAB9AHDAC3 | |
| SCHEMBL25856348 | 0.74 | MAPT (0.48) | MAPTTP53RAF1NPC1RAB9A | |
| SCHEMBL25308935 | 0.73 | MAPT (0.67) | MAPTTP53NPC1RAB9AHDAC3 | |
| SCHEMBL25263437 | 0.73 | MAPT (0.52) | MAPTTP53NPC1RAB9AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023130540-A1 | PYRAZOL BENZAMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 苏州大学 | 2023-07-13 | — | — | WO | disclosed |
| WO-2023130540-A1 | PYRAZOL BENZAMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 苏州大学 | 2023-07-13 | — | — | WO | disclosed |
| CN-114394934-B | Pyrazole benzamide compound as well as preparation method and application thereof | 苏州大学 | 2023-06-13 | — | — | CN | disclosed |
| CN-114394934-A | Pyrazole benzamide compound and preparation method and application thereof | 苏州大学 | 2022-04-26 | — | — | CN | disclosed |