Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9766008 | 0.84 | SIGMAR1 (0.60) | SIGMAR1HTR1AKDM4ECYP1A2GAA | |
| SCHEMBL26129134 | 0.82 | PPARG (0.46) | PPARGPPARDPPARATIPARP | |
| SCHEMBL25223898 | 0.82 | SIGMAR1 (0.48) | SIGMAR1HTR1AKDM4ECYP1A2GAA | |
| SCHEMBL27233837 | 0.81 | TIPARP (0.47) | SIGMAR1HTR1APPARGPPARDPPARA | |
| SCHEMBL26133414 | 0.81 | SIGMAR1 (0.47) | SIGMAR1HTR1APPARGPPARDPPARA | |
| SCHEMBL24968330 | 0.80 | PPARG (0.44) | SIGMAR1HTR1APPARGPPARDPPARA | |
| SCHEMBL17832213 | 0.79 | OGA (0.43) | PPARGPPARDPPARATIPARP | |
| SCHEMBL26134112 | 0.79 | SIGMAR1 (0.43) | SIGMAR1HTR1APPARGPPARDPPARA | |
| SCHEMBL25311331 | 0.78 | HTR1A (0.47) | HTR1ACYP1A2DRD2 | |
| SCHEMBL31464998 | 0.77 | PPARG (0.48) | SIGMAR1HTR1APPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |