Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 5/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.39 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25308826 | 0.82 | SMN1; SMN2 (0.45) | ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL30510783 | 0.82 | SMN1; SMN2 (0.45) | ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL25307357 | 0.78 | SIGMAR1 (0.44) | HTR1ADRD2CYP1A2 | |
| SCHEMBL25309387 | 0.73 | TRPA1 (0.39) | HTR1ATRPA1DRD3DRD2ALDH1A1 | |
| SCHEMBL30510789 | 0.73 | TRPA1 (0.39) | HTR1ATRPA1DRD3DRD2ALDH1A1 | |
| SCHEMBL25268518 | 0.70 | DRD2 (0.53) | HTR1ADRD3DRD2HTR2AHTR7 | |
| SCHEMBL25223898 | 0.69 | SIGMAR1 (0.48) | HTR1ADRD3DRD2HTR2ACYP1A2 | |
| SCHEMBL27233837 | 0.69 | TIPARP (0.47) | HTR1ADRD3DRD2HTR2AADRA2C | |
| SCHEMBL25310691 | 0.69 | TRPA1 (0.41) | HTR1ATRPA1ALDH1A1DRD4 | |
| SCHEMBL30510832 | 0.69 | TRPA1 (0.41) | HTR1ATRPA1ALDH1A1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |