Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.44 |
| ▸ | TNKS | O95271 | 5/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TIPARP | Q7Z3E1 | 5/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | PARP8 | Q8N3A8 | 1/20 | 0.38 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.38 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25310465 | 0.90 | TIPARP (0.46) | PARP1TNKSPARP2MAPTTIPARP | |
| SCHEMBL25308789 | 0.84 | TNKS (0.51) | PARP1TNKSMAPTTIPARPSMN1; SMN2 | |
| SCHEMBL25309030 | 0.82 | TIPARP (0.63) | PARP1TNKSTIPARPROCK2ROCK1 | |
| SCHEMBL25309796 | 0.80 | TIPARP (0.67) | PARP1TIPARPROCK2ROCK1 | |
| SCHEMBL25309636 | 0.79 | TIPARP (0.59) | PARP1TNKSTIPARPROCK2ROCK1 | |
| SCHEMBL25309989 | 0.79 | PARP1 (0.46) | PARP1TNKSPARP2MAPTTIPARP | |
| SCHEMBL30510755 | 0.79 | PARP1 (0.53) | PARP1TNKSPARP2MAPTTIPARP | |
| SCHEMBL25308758 | 0.79 | PARP1 (0.53) | PARP1TNKSPARP2MAPTTIPARP | |
| SCHEMBL25309193 | 0.78 | PARP1 (0.51) | PARP1MAPTTIPARP | |
| SCHEMBL30510763 | 0.78 | KMT2A (0.57) | PARP1MAPTTIPARPSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |