Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30510806 | 1.00 | JAK1 (0.49) | JAK1JAK2TYK2JAK3ACACB | |
| SCHEMBL25310830 | 0.88 | KMT2A (0.53) | MEN1KMT2A | |
| SCHEMBL30510779 | 0.88 | KMT2A (0.53) | MEN1KMT2A | |
| SCHEMBL24962970 | 0.83 | GPR119 (0.57) | JAK1JAK2TYK2JAK3ACACB | |
| SCHEMBL25309474 | 0.80 | HDAC1 (0.57) | ACACBHDAC1GPR119HSD11B1MEN1 | |
| SCHEMBL30165102 | 0.80 | HDAC1 (0.57) | ACACBHDAC1GPR119HSD11B1MEN1 | |
| SCHEMBL31027289 | 0.80 | MEN1 (0.57) | GPR119CXCR3MEN1KMT2ASLC6A9 | |
| SCHEMBL4903232 | 0.80 | MEN1 (0.57) | GPR119CXCR3MEN1KMT2ASLC6A9 | |
| SCHEMBL20071202 | 0.77 | JAK1 (0.43) | JAK1JAK2TYK2JAK3HDAC1 | |
| SCHEMBL31458782 | 0.77 | JAK1 (0.43) | JAK1JAK2TYK2JAK3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |