Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30510779 | 1.00 | KMT2A (0.53) | KMT2AMEN1SMN1; SMN2LMNAMAPT | |
| SCHEMBL25308802 | 0.88 | JAK1 (0.49) | KMT2AMEN1 | |
| SCHEMBL30510806 | 0.88 | JAK1 (0.49) | KMT2AMEN1 | |
| SCHEMBL23064388 | 0.84 | HDAC1 (0.46) | MAPTCYP2C9CYP2C19GAA | |
| SCHEMBL24962970 | 0.82 | GPR119 (0.57) | — | |
| SCHEMBL2366233 | 0.80 | KMT2A (0.76) | KMT2AMEN1SMN1; SMN2LMNAMAPT | |
| SCHEMBL31142882 | 0.80 | KMT2A (0.76) | KMT2AMEN1SMN1; SMN2LMNAMAPT | |
| SCHEMBL16771100 | 0.79 | GPR119 (0.51) | KMT2AMEN1SMN1; SMN2MAPTCYP2C9 | |
| SCHEMBL30165102 | 0.79 | HDAC1 (0.57) | KMT2AMEN1SMN1; SMN2LMNAMAPT | |
| SCHEMBL25309474 | 0.79 | HDAC1 (0.57) | KMT2AMEN1SMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |