Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 7/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25309904 | 0.88 | PARP1 (0.52) | SMN1; SMN2ALDH1A1PARP1POLBAR | |
| SCHEMBL25310305 | 0.74 | ALDH1A1 (0.76) | SMN1; SMN2ALDH1A1TSHRPARP1POLB | |
| SCHEMBL1859515 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL29060217 | 0.72 | L3MBTL1 (0.44) | SMN1; SMN2ALDH1A1POLBLMNAKMT2A | |
| SCHEMBL9902801 | 0.72 | L3MBTL1 (0.51) | SMN1; SMN2ALDH1A1POLBLMNAKMT2A | |
| SCHEMBL5010738 | 0.71 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1TSHRPARP1POLB | |
| SCHEMBL25309821 | 0.71 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1TSHRPARP1POLB | |
| SCHEMBL7317841 | 0.70 | L3MBTL1 (0.49) | SMN1; SMN2ALDH1A1POLBLMNAKMT2A | |
| SCHEMBL21575767 | 0.69 | PRMT5 (0.64) | SMN1; SMN2ALDH1A1TSHRPARP1POLB | |
| SCHEMBL30231202 | 0.69 | PRMT5 (0.68) | SMN1; SMN2ALDH1A1TSHRPARP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |