Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 12/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TNKS | O95271 | 2/20 | 0.48 |
| ▸ | TIPARP | Q7Z3E1 | 3/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25307742 | 0.97 | TIPARP (0.51) | ROCK2ROCK1PARP1KMT2ATNKS | |
| SCHEMBL25309218 | 0.94 | ROCK2 (0.52) | ROCK2ROCK1PARP1KMT2ATNKS | |
| SCHEMBL25309242 | 0.90 | PARP1 (0.52) | ROCK2ROCK1PARP1KMT2ATNKS | |
| SCHEMBL25310638 | 0.90 | ROCK2 (0.61) | ROCK2ROCK1PARP1KMT2ATNKS | |
| SCHEMBL25263299 | 0.89 | TNKS (0.53) | PARP1KMT2ATNKSTIPARPPARP2 | |
| SCHEMBL25309030 | 0.88 | TIPARP (0.63) | ROCK2ROCK1PARP1KMT2ATNKS | |
| SCHEMBL25310803 | 0.88 | PARP1 (0.61) | ROCK2ROCK1PARP1KMT2ATNKS | |
| SCHEMBL25307126 | 0.88 | KMT2A (0.48) | ROCK2ROCK1PARP1KMT2ATNKS | |
| SCHEMBL25311711 | 0.88 | KMT2A (0.48) | ROCK2ROCK1PARP1KMT2ATNKS | |
| SCHEMBL30510758 | 0.87 | KMT2A (0.47) | ROCK2ROCK1PARP1KMT2ATNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |