Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 6/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7924131 | 0.82 | ALDH1A1 (0.62) | KMT2AMEN1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL7935215 | 0.81 | ALDH1A1 (0.61) | KMT2AMEN1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL12225960 | 0.79 | ALDH1A1 (0.65) | KMT2AMEN1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL1493401 | 0.78 | ALDH1A1 (0.64) | KMT2AMEN1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL12225978 | 0.76 | KMT2A (0.61) | KMT2AMEN1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL1493466 | 0.74 | ALDH1A1 (0.72) | KMT2AMEN1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL23009199 | 0.74 | ALDH1A1 (0.63) | KMT2AMEN1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL2538104 | 0.72 | MEN1 (0.58) | KMT2AMEN1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL7936741 | 0.70 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1TSHRNPSR1HTT | |
| SCHEMBL28299784 | 0.70 | ALDH1A1 (0.79) | KMT2AMEN1ALDH1A1L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110257177-A1 | BENZYLTHIOTETRAZOLE INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| WO-2010034003-A2 | BENZYLTHIOTETRAZOLE INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA, INC. (US) | 2010-03-25 | — | — | WO | disclosed |
| WO-2010034003-A2 | BENZYLTHIOTETRAZOLE INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA, INC. (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257177-A1 | BENZYLTHIOTETRAZOLE INHIBITORS OF STORE OPERATED CALCIUM RELEASE | SARAF, CACNA1I, ORAI1 | KMT2A 4508/4885MEN1 3317/4885ALDH1A1 4357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.