SCHEMBL253099

SCHEMBL253099

COc1cccc(OC)c1I

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 4/20 0.58
CA2 P00918 4/20 0.58
CA7 P43166 3/20 0.58
CA9 Q16790 3/20 0.58
CA12 O43570 2/20 0.58
CA14 Q9ULX7 2/20 0.58
CA4 P22748 1/20 0.58
ALDH1A1 P00352 3/20 0.50
TP53 P04637 2/20 0.50
MAPK1 P28482 2/20 0.50
MAPT P10636 2/20 0.50
HPGD P15428 2/20 0.50
KDM4E B2RXH2 1/20 0.50
LMNA P02545 1/20 0.50
CYP3A4 P08684 1/20 0.50
ALOX15 P16050 1/20 0.50
ALOX12 P18054 1/20 0.50
HSD17B10 Q99714 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.46
TSHR P16473 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25874735 0.92 CA1 (0.50) CA1CA2CA7CA9CA12
SCHEMBL16590519 0.87 CA1 (0.50) CA1CA2CA7CA9CA12
SCHEMBL4136425 0.87 CA1 (0.50) CA1CA2CA7CA9CA12
SCHEMBL12311883 0.85 CA1 (0.48) CA1CA2CA7CA9CA12
SCHEMBL30918934 0.85 CA1 (0.48) CA1CA2CA7CA9CA12
SCHEMBL16257301 0.84 NPSR1 (0.42) CA1CA2CA7CA9CA12
SCHEMBL19573863 0.84 SMN1; SMN2 (0.45) CA1CA2CA7CA9CA12
SCHEMBL23885410 0.83 ALDH1A1 (0.60) CA1CA2CA7CA9CA12
SCHEMBL2045969 0.83 MAPT (0.64) CA1CA2CA7CA9CA12
SCHEMBL4185526 0.83 CA1 (0.46) CA1CA2CA7CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 181 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115894184-B Method for preparing di (2, 6-dimethoxy phenyl) triethylene glycol 黎明化工研究设计院有限责任公司 2024-07-05 CN claimed
CN-113087689-B Simple synthesis method of 5-amino-gamma-lactone derivative 中国人民解放军空军军医大学 2023-09-29 CN claimed
CN-115894184-A Method for preparing di (2, 6-dimethoxyphenyl) triethylene glycol 黎明化工研究设计院有限责任公司 2023-04-04 CN claimed
CN-110981838-B 5-imine-tetrahydrofuryl methylamine derivative and preparation method and application thereof 中国人民解放军第四军医大学 2023-03-24 CN claimed
CN-113087689-A Simple synthesis method of 5-amino-gamma-lactone derivative 中国人民解放军空军军医大学 2021-07-09 CN claimed
CN-106748604-B Method for synthesizing mono-iodo aromatic hydrocarbon or di-iodo aromatic hydrocarbon based on decarboxylation of aromatic carboxylic acid 湘潭大学 2020-06-05 CN claimed
CN-110981838-A 5-imine-tetrahydrofuryl methylamine derivative and preparation method and application thereof 中国人民解放军第四军医大学 2020-04-10 CN claimed
CN-106748604-A A kind of method for synthesizing single iodo aromatic hydrocarbon or two iodo aromatic hydrocarbons based on aromatic carboxylic acid's decarboxylic reaction 湘潭大学 2017-05-31 CN claimed
US-20030069427-A1 Process for the preparation of 5-(substituted)-10 methoxy-2,2,4-trimethyl-2,5-dihydro- 1H-chromeno [3,4-f] quinolines and derivatives thereof ABBVIE INC. 2003-04-10 US claimed
WO-2003027117-A1 A PROCESS FOR THE PREPARATION OF 5-(SUBSTITUTED)-10-METHOXY-2,2,4-TRIMETHYL-2,5-DIHYDRO-1H-CHROMENO[3,4-F]QUINOLINES AND DERIVATIVES THEREOF ABBOTT LABORATORIES (US) 2003-04-03 WO claimed
US-6518430-B1 The present invention relates to an efficient process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5- dihydro-1H-chromeno(3,4-f)quinolines. ABBOTT LABORATORIES 2003-02-11 US claimed
US-20250243229-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2025-07-31 US disclosed
US-20250236621-A1 5- AND 6-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES ENLIVEN INC. 2025-07-24 US disclosed
CN-120040505-A Phosphorus phenol ligand, phosphorus phenol complex, preparation method and application thereof, and ethylene polymerization method 南开大学 2025-05-27 CN disclosed
US-12297212-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2025-05-13 US disclosed
WO-2003027117-A1 A PROCESS FOR THE PREPARATION OF 5-(SUBSTITUTED)-10-METHOXY-2,2,4-TRIMETHYL-2,5-DIHYDRO-1H-CHROMENO[3,4-F]QUINOLINES AND DERIVATIVES THEREOF ABBOTT LABORATORIES (US) 2003-04-03 WO disclosed
US-6518430-B1 The present invention relates to an efficient process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5- dihydro-1H-chromeno(3,4-f)quinolines. ABBOTT LABORATORIES 2003-02-11 US disclosed
US-20010041674-A1 C-glycosides and preparation of thereof as antidiabetic agents KOTOBUJKI PHARMACEUTICAL CO., LTD. 2001-11-15 US disclosed
US-4879398-A Process for producing 2,6-disubstituted tyrosine MONSANTO COMPANY (US) 1989-11-07 US disclosed
US-3992273-A Method of preparing substituted phenyl phosphinic acids MONSANTO COMPANY (US) 1976-11-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010041674-A1 C-glycosides and preparation of thereof as antidiabetic agents GCG, SLC5A1, SLC5A2 CA1 431/4885CA2 147/4885CA7 23/4885
US-20250243229-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES F5, OR10J3, NPY4R CA1 2594/4885CA2 2469/4885CA7 2325/4885
US-20250236621-A1 5- AND 6-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES ABL1, ABL2, BCR CA1 4735/4885CA2 4223/4885CA7 3708/4885
US-12297212-B2 Organic electroluminescent materials and devices OCIAD2, OCIAD1, OR10J3 CA1 3917/4885CA2 3349/4885CA7 2050/4885
US-20030069427-A1 Process for the preparation of 5-(substituted)-10 methoxy-2,2,4-trimethyl-2,5-dihydro- 1H-chromeno [3,4-f] quinolines and derivatives thereof HTR3C, CYP3A5, NQO2 CA1 4803/4885CA2 4014/4885CA7 3313/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.