Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL25309672 | 0.99 | PARP1 (0.46) | PARP1LMNASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL25307526 | 0.80 | PARP1 (0.42) | PARP1LMNATNKS | |
| SCHEMBL25308646 | 0.80 | PARP1 (0.42) | PARP1LMNASMN1; SMN2ALDH1A1BRD4 | |
| SCHEMBL30510773 | 0.79 | HTR1A (0.43) | PARP1LMNABRD4TNKS | |
| SCHEMBL25307141 | 0.79 | HTR1A (0.43) | PARP1LMNABRD4TNKS | |
| SCHEMBL25310262 | 0.78 | PARP1 (0.44) | PARP1LMNATNKS | |
| SCHEMBL30510768 | 0.78 | PARP1 (0.38) | PARP1LMNASMN1; SMN2ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL25310952 | 0.77 | PARP1 (0.55) | PARP1LMNASMN1; SMN2PRMT5KMT2A | |
| SCHEMBL30510764 | 0.77 | CHRM1 (0.49) | PARP1TNKS | |
| SCHEMBL30510776 | 0.77 | PARP1 (0.39) | PARP1LMNASMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |