Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 6/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30510773 | 1.00 | HTR1A (0.43) | HTR1ADRD4HTR2ASLC6A4HTR7 | |
| SCHEMBL25308646 | 0.89 | PARP1 (0.42) | PARP1TNKSLMNATDP1HTT | |
| SCHEMBL30510764 | 0.87 | CHRM1 (0.49) | PARP1TNKSCHRM1 | |
| SCHEMBL25309923 | 0.87 | PARP1 (0.41) | PARP1TNKSLMNATDP1CHRM1 | |
| SCHEMBL30510762 | 0.87 | PARP1 (0.41) | PARP1TNKSLMNATDP1CHRM1 | |
| SCHEMBL25309578 | 0.87 | SPR (0.43) | PARP1TNKSLMNA | |
| SCHEMBL25310671 | 0.87 | CHRM1 (0.49) | PARP1TNKSCHRM1 | |
| SCHEMBL25263299 | 0.84 | TNKS (0.53) | PARP1TNKSLMNACHRM1 | |
| SCHEMBL25307526 | 0.82 | PARP1 (0.42) | PARP1TNKSLMNA | |
| SCHEMBL25311716 | 0.80 | PARP1 (0.42) | PARP1TNKSLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |