Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL51354 | 0.86 | DAO (0.38) | HTR1AL3MBTL1ALDH1A1KDM4EHPGD | |
| SCHEMBL3941964 | 0.74 | RPS6KA3 (0.43) | — | |
| SCHEMBL841220 | 0.74 | ALDH1A1 (0.42) | HTR1AL3MBTL1ALDH1A1SIGMAR1 | |
| SCHEMBL3938873 | 0.74 | RPS6KA3 (0.45) | L3MBTL1ALDH1A1KDM4EKMT2AHSD17B10 | |
| SCHEMBL3946964 | 0.70 | RPS6KA2 (0.41) | ALDH1A1 | |
| SCHEMBL2421457 | 0.68 | KDM4E (0.49) | HTR1AALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL641455 | 0.64 | KMT2A (0.37) | HTR1AALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL51096 | 0.62 | MCL1 (0.38) | L3MBTL1ALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL854124 | 0.61 | KMT2A (0.34) | L3MBTL1ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL50820 | 0.61 | RPS6KA3 (0.49) | ALDH1A1KDM4EHPGDKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401280-A1 | Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors | Bristol-Myers Squibb Company (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010099159-A1 | CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-09-02 | — | — | WO | disclosed |