Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.61 |
| ▸ | PARP1 | P09874 | 10/20 | 0.60 |
| ▸ | TNKS | O95271 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25310750 | 0.90 | ROCK2 (0.50) | ROCK2ROCK1PARP1TNKSTSHR | |
| SCHEMBL25309242 | 0.90 | PARP1 (0.52) | ROCK2ROCK1PARP1TNKSTSHR | |
| SCHEMBL25310803 | 0.87 | PARP1 (0.61) | ROCK2ROCK1PARP1TNKSKMT2A | |
| SCHEMBL25309030 | 0.87 | TIPARP (0.63) | ROCK2ROCK1PARP1TNKSKMT2A | |
| SCHEMBL25307126 | 0.87 | KMT2A (0.48) | ROCK2ROCK1PARP1TNKSTSHR | |
| SCHEMBL25311711 | 0.87 | KMT2A (0.48) | ROCK2ROCK1PARP1TNKSTSHR | |
| SCHEMBL25307742 | 0.87 | TIPARP (0.51) | ROCK2ROCK1PARP1TNKSTSHR | |
| SCHEMBL25308938 | 0.86 | TNKS (0.57) | ROCK2ROCK1PARP1TNKSTSHR | |
| SCHEMBL25309796 | 0.85 | TIPARP (0.67) | ROCK2ROCK1PARP1KMT2A | |
| SCHEMBL30510758 | 0.83 | KMT2A (0.47) | ROCK2ROCK1PARP1TNKSKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |