Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 11/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25310056 | 0.86 | TNKS (0.49) | TNKSKMT2APARP1CHRM1PARP2 | |
| SCHEMBL30510778 | 0.86 | TNKS (0.49) | TNKSKMT2APARP1CHRM1PARP2 | |
| SCHEMBL25310638 | 0.86 | ROCK2 (0.61) | TNKSKMT2APARP1ALDH1A1ROCK2 | |
| SCHEMBL25263299 | 0.85 | TNKS (0.53) | TNKSKMT2APARP1HSD17B10CHRM1 | |
| SCHEMBL25307410 | 0.84 | TNKS (0.55) | TNKSKMT2APARP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL25309242 | 0.82 | PARP1 (0.52) | TNKSKMT2APARP1ROCK2ROCK1 | |
| SCHEMBL25310750 | 0.82 | ROCK2 (0.50) | TNKSKMT2APARP1ROCK2ROCK1 | |
| SCHEMBL25310532 | 0.82 | PARP1 (0.62) | TNKSPARP1PARP2 | |
| SCHEMBL25308789 | 0.82 | TNKS (0.51) | TNKSKMT2APARP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL25309465 | 0.82 | TNKS (0.49) | TNKSKMT2APARP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |