Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.53 |
| ▸ | ME2 | P23368 | 2/20 | 0.48 |
| ▸ | ME1 | P48163 | 2/20 | 0.48 |
| ▸ | ME3 | Q16798 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 11/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.45 |
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25310750 | 0.89 | ROCK2 (0.50) | TNKSPARP1KMT2APARP2TIPARP | |
| SCHEMBL25309465 | 0.86 | TNKS (0.49) | TNKSPARP1KMT2ALMNAMAPK1 | |
| SCHEMBL30510766 | 0.86 | TNKS (0.49) | TNKSPARP1KMT2ALMNAMAPK1 | |
| SCHEMBL25310532 | 0.86 | PARP1 (0.62) | TNKSPARP1PARP2TIPARP | |
| SCHEMBL25308789 | 0.86 | TNKS (0.51) | TNKSPARP1KMT2ACHRM1TIPARP | |
| SCHEMBL25307742 | 0.86 | TIPARP (0.51) | TNKSPARP1KMT2ATIPARPLMNA | |
| SCHEMBL25308938 | 0.85 | TNKS (0.57) | TNKSPARP1KMT2ACHRM1PARP2 | |
| SCHEMBL30510772 | 0.84 | TNKS (0.51) | TNKSME2ME1ME3PARP1 | |
| SCHEMBL30510770 | 0.84 | TNKS (0.51) | TNKSME2ME1ME3PARP1 | |
| SCHEMBL25307141 | 0.84 | HTR1A (0.43) | TNKSPARP1CHRM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |