Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.42 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1333584 | 0.80 | CYP1A2 (0.61) | ALDH1A1MAPTKDM4ETDP1CYP1A2 | |
| SCHEMBL26633220 | 0.79 | SCN9A (0.52) | KCNH2 | |
| SCHEMBL17978906 | 0.79 | HRH3 (0.40) | ALDH1A1MAPTKDM4ETDP1KCNH2 | |
| SCHEMBL25315094 | 0.79 | HRH3 (0.40) | ALDH1A1KCNH2 | |
| SCHEMBL17477132 | 0.74 | MAPT (0.44) | ALDH1A1MAPTKDM4ETDP1CYP1A2 | |
| SCHEMBL21689064 | 0.74 | MEN1 (0.53) | ALDH1A1MAPTKDM4EADRB1SIRT6 | |
| SCHEMBL17633311 | 0.74 | HSPB1 (0.53) | MAPTTDP1HSPB1CYP1A2LMNA | |
| SCHEMBL19617917 | 0.74 | GPR119 (0.38) | ALDH1A1MAPTKDM4ECYP2D6MGLL | |
| SCHEMBL31732979 | 0.74 | GPR119 (0.38) | ALDH1A1MAPTKDM4ECYP2D6MGLL | |
| SCHEMBL6626480 | 0.73 | ADRA2A (0.51) | MAPTHSPB1CYP1A2LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125908-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2023-07-06 | — | — | WO | disclosed |
| CN-1829691-A | Pyridyl derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2006-09-06 | — | — | CN | disclosed |