Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyrrolidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrrolidine SCHEMBL16241174 | 0.98 | ALDH1A1 (0.45) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| Piperidine SCHEMBL4867261 | 0.98 | ALDH1A1 (0.45) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| Piperidine SCHEMBL631560 | 0.98 | ALDH1A1 (0.45) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| Piperidine SCHEMBL16927692 | 0.96 | ALDH1A1 (0.44) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| Azetidine SCHEMBL28290955 | 0.96 | ALDH1A1 (0.49) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| Aziridine SCHEMBL5185484 | 0.94 | ALDH1A1 (0.50) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| Piperazine SCHEMBL5875357 | 0.92 | ALDH1A1 (0.49) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| Piperazine SCHEMBL7635861 | 0.92 | ALDH1A1 (0.49) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| Cyclohexane SCHEMBL27563472 | 0.86 | GAA (0.54) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| Cyclopropane SCHEMBL2101355 | 0.86 | GAA (0.54) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119080615-A | Method for preparing long-chain dibasic acid or dibasic ester | 中国科学院大连化学物理研究所 | 2024-12-06 | — | — | CN | claimed |
| WO-2026085629-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | Université de Montréal (CA) | 2026-04-30 | — | — | WO | disclosed |
| CN-119080615-A | Method for preparing long-chain dibasic acid or dibasic ester | 中国科学院大连化学物理研究所 | 2024-12-06 | — | — | CN | disclosed |
| CN-108290881-A | Therapeutic compounds and methods of use thereof | 健泰科生物技术公司 | 2018-07-17 | — | — | CN | disclosed |
| CN-108069955-A | 3- pyridyl group -4- benzothiazolyls pyrazole derivatives, its preparation method and its application in medicine | 江苏恒瑞医药股份有限公司 | 2018-05-25 | — | — | CN | disclosed |
| US-8877927-B2 | Furo[3,2-B] pyrrol -3-one derivatives and their use as cysteinyl proteinase inhibitors | GRUNENTHAL GMBH (DE) | 2014-11-04 | — | — | US | disclosed |
| CN-102112473-B | Pyrrolidinyl-alkyl-amide derivatives, process for their preparation and their therapeutic use as CCR3 receptor ligands | SANOFI AVENTIS | 2014-08-20 | — | — | CN | disclosed |
| US-8629287-B2 | Process for the sulfinylation of a pyrazole derivative | BASF SE (DE) | 2014-01-14 | — | — | US | disclosed |
| EP-2081909-B1 | PROCESS FOR THE SULFINYLATION OF A PYRAZOLE DERIVATIVE | BASF SE (DE) | 2013-01-09 | — | — | EP | disclosed |
| EP-2081919-B1 | TETRAHYDROFURO [3, 2-B]PYRR0L-3-0NE INTERMEDIATES | AMURA THERAPEUTICS LTD (GB) | 2012-05-23 | — | — | EP | disclosed |
| EP-2081919-A1 | TETRAHYDROFURO [3, 2-B]PYRR0L-3-0NE INTERMEDIATES | Amura Therapeutics Limited (GB) | 2009-07-29 | — | — | EP | disclosed |
| EP-2081909-A1 | PROCESS FOR THE SULFINYLATION OF A PYRAZOLE DERIVATIVE | BASF SE (DE) | 2009-07-29 | — | — | EP | disclosed |
| EP-2046797-A1 | FURO [3,2-B]PYRROL-3-ONE DERIVATIVES AND THEIR USE AS CYSTEINYL PROTEINASE INHIBITORS | Amura Therapeutics Limited (GB) | 2009-04-15 | — | — | EP | disclosed |
| US-7402684-B2 | Biaryl substituted heterocycle inhibitors of LTA4H for treating inflammation | DECODE GENECTICS EHF. (IS) | 2008-07-22 | — | — | US | disclosed |
| EP-1926708-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | Decode Chemistry, Inc. (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2008055879-A1 | PROCESS FOR THE SULFINYLATION OF A PYRAZOLE DERIVATIVE | BASF SE (DE) | 2008-05-15 | — | — | WO | disclosed |
| WO-2008007127-A1 | FURO [3,2-B] PYRROL-3-ONE DERIVATIVES AND THEIR USE AS CYSTEINYL PROTEINASE INHIBITORS | AMURA THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008007132-A1 | TETRAHYDROFURO [3, 2-B] PYRR0L-3-0NE INTERMEDIATES | AMURA THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |
| WO-2007040681-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007040682-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF. (IS) | 2007-04-12 | — | — | WO | disclosed |