SCHEMBL25322976

SCHEMBL25322976

N=Cc1cn(Cc2ccccc2)c2cc(Cl)ccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA3 P22001 9/20 0.47
ALDH1A1 P00352 4/20 0.46
MAPT P10636 2/20 0.46
HTT P42858 2/20 0.46
NPSR1 Q6W5P4 2/20 0.46
ALOX12 P18054 1/20 0.46
MEN1 O00255 1/20 0.46
CYP1A2 P05177 1/20 0.46
HSP90AA1 P07900 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
KMT2A Q03164 1/20 0.46
ATM Q13315 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
SNCA P37840 1/20 0.45
SCN2A Q99250 1/20 0.44
NR4A1 P22736 1/20 0.44
CNR1 P21554 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17829679 0.86 ALDH1A1 (0.57) KCNA3ALDH1A1MAPTHTTNPSR1
SCHEMBL28522604 0.86 KCNA3 (0.47) KCNA3ALDH1A1MAPTHTTNPSR1
SCHEMBL28735622 0.83 ALDH1A1 (0.62) ALDH1A1MAPTHTTNPSR1MEN1
SCHEMBL28478660 0.78 ALDH1A1 (0.57) ALDH1A1MAPTHTTNPSR1ALOX12
SCHEMBL25322499 0.77 PTGS2 (0.54) ALDH1A1MAPTHTTNPSR1ALOX12
SCHEMBL16587064 0.76 ENPP2 (0.53) ALDH1A1MAPTHTTNPSR1ALOX12
SCHEMBL16587063 0.76 ENPP2 (0.53) ALDH1A1MAPTHTTNPSR1ALOX12
SCHEMBL28238248 0.76 ALDH1A1 (0.49) ALDH1A1MAPTHTTNPSR1ALOX12
SCHEMBL17829696 0.74 ALDH1A1 (0.60) ALDH1A1MAPTHTTNPSR1ALOX12
SCHEMBL3105145 0.74 SERPINE1 (0.59) ALDH1A1MAPTHTTNPSR1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023137771-A1 METHOD FOR SYNTHESIZING α-ALKYL SUBSTITUTED INDOLE-3-CARBOXALDEHYDE COMPOUND 苏州大学 2023-07-27 WO disclosed