Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25322450 | 0.77 | RIPK1 (0.50) | RIPK1 | |
| SCHEMBL25917618 | 0.77 | RIPK1 (0.50) | RIPK1 | |
| SCHEMBL25322454 | 0.77 | RIPK1 (0.50) | RIPK1 | |
| SCHEMBL10091151 | 0.74 | ESR2 (0.46) | RIPK1KDM1ARCOR1HTR2AHTR2C | |
| SCHEMBL27273287 | 0.74 | ESR2 (0.46) | RIPK1KDM1ARCOR1HTR2AHTR2C | |
| SCHEMBL4294410 | 0.71 | RIPK1 (0.50) | RIPK1MAOBMAOAALDH1A1 | |
| SCHEMBL10091161 | 0.70 | ESR2 (0.42) | RIPK1KDM1ARCOR1HTR2AHTR2C | |
| SCHEMBL20843446 | 0.70 | MAOB (0.45) | RIPK1MAOBMAOASLC6A2SLC6A4 | |
| SCHEMBL21859861 | 0.69 | CHRNB2 (0.64) | RIPK1ALDH1A1 | |
| SCHEMBL20703257 | 0.69 | RIPK1 (0.58) | RIPK1MAOBMAOAHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |