Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 3/20 | 0.31 |
| ▸ | KDR | P35968 | 3/20 | 0.31 |
| ▸ | CLK1 | P49759 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30522987 | 1.00 | ALDH1A1 (0.34) | ALDH1A1HSD17B10PRMT5WDR77CRBN | |
| SCHEMBL25913598 | 1.00 | ALDH1A1 (0.34) | ALDH1A1HSD17B10PRMT5WDR77CRBN | |
| SCHEMBL25327271 | 1.00 | ALDH1A1 (0.34) | ALDH1A1HSD17B10PRMT5WDR77CRBN | |
| SCHEMBL25324534 | 1.00 | ALDH1A1 (0.34) | ALDH1A1HSD17B10PRMT5WDR77CRBN | |
| SCHEMBL30470212 | 0.82 | PRMT5 (0.39) | ALDH1A1HSD17B10PRMT5WDR77SLC6A2 | |
| SCHEMBL30470799 | 0.82 | PRMT5 (0.39) | ALDH1A1HSD17B10PRMT5WDR77SLC6A2 | |
| SCHEMBL25320666 | 0.82 | PRMT5 (0.39) | ALDH1A1HSD17B10PRMT5WDR77SLC6A2 | |
| SCHEMBL25670004 | 0.82 | PRMT5 (0.39) | ALDH1A1HSD17B10PRMT5WDR77SLC6A2 | |
| SCHEMBL24365117 | 0.82 | PRMT5 (0.39) | ALDH1A1HSD17B10PRMT5WDR77SLC6A2 | |
| SCHEMBL31254514 | 0.80 | METTL3 (0.34) | ALDH1A1HSD17B10PRMT5WDR77SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250282749-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2025-09-11 | — | — | US | disclosed |
| EP-4469445-A1 | COMPOUNDS AND METHODS OF USE | Tango Therapeutics, Inc. (US) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023146991-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250282749-A1 | COMPOUNDS AND METHODS OF USE | CYP1B1, CYP2C19, UGT1A1 | ALDH1A1 193/4885HSD17B10 523/4885PRMT5 2082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.