SCHEMBL25325213

SCHEMBL25325213

CCSc1c(-c2nccn2C)nc2ccc(C(F)(F)F)cn12

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 8/20 0.40
KDM4E B2RXH2 3/20 0.35
ALDH1A1 P00352 3/20 0.35
RXFP1 Q9HBX9 1/20 0.35
HSD17B10 Q99714 1/20 0.34
NR1H4 Q96RI1 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
SLC2A1 P11166 1/20 0.33
DRD3 P35462 1/20 0.33
KCNH2 Q12809 1/20 0.33
USP7 Q93009 1/20 0.33
EIF2AK4 Q9P2K8 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25911700 0.82 TRPA1 (0.40) TRPA1KDM4EALDH1A1RXFP1HSD17B10
SCHEMBL25326279 0.81 TRPA1 (0.39) TRPA1KDM4EALDH1A1RXFP1HSD17B10
SCHEMBL25328877 0.80 TRPA1 (0.44) TRPA1KDM4EALDH1A1RXFP1HSD17B10
SCHEMBL19992636 0.76 TRPA1 (0.41) TRPA1KDM4ERXFP1HSD17B10NR1H4
SCHEMBL19992537 0.75 TRPA1 (0.39) TRPA1KDM4EALDH1A1HSD17B10NR1H4
SCHEMBL19992536 0.75 TRPA1 (0.44) TRPA1KDM4EALDH1A1HSD17B10NR1H4
SCHEMBL23131664 0.74 TRPA1 (0.41) TRPA1KDM4EALDH1A1RXFP1HSD17B10
SCHEMBL22303136 0.74 TRPA1 (0.46) TRPA1KDM4EALDH1A1RXFP1HSD17B10
SCHEMBL22519297 0.74 USP7 (0.50) TRPA1KDM4EALDH1A1RXFP1HSD17B10
SCHEMBL19711917 0.74 TRPA1 (0.38) TRPA1KDM4EALDH1A1RXFP1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230357232-A1 IMIDAZO[1,2-A]PYRIDINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2023-11-09 US disclosed
US-20230357232-A1 IMIDAZO[1,2-A]PYRIDINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2023-11-09 US disclosed
EP-4219491-A1 IMIDAZO[1,2-A]PYRIDINE COMPOUND AND PEST CONTROL AGENT Nippon Soda Co., Ltd. (JP) 2023-08-02 EP disclosed
WO-2022065235-A1 IMIDAZO[1,2-A]PYRIDINE COMPOUND AND PEST CONTROL AGENT 日本曹達株式会社 2022-03-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230357232-A1 IMIDAZO[1,2-A]PYRIDINE COMPOUND AND PEST CONTROL AGENT CTRL, CBR3, ITPR3 TRPA1 490/4885KDM4E 571/4885ALDH1A1 2175/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.