ITPR3

Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 · Q14573 · ITPR3 on Sugi Atlas →

2,486 patent compounds predicted against ITPR3, 1,658 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4348223	0.56	10/20
SCHEMBL142299	0.45	10/20
Ins(1,4,5)P3 (SCHEMBL98182)	1.00	9/20
Ins(1,4,5)P3 (SCHEMBL381458)	1.00	9/20
Ins(1,4,5)P3 (SCHEMBL382820)	1.00	9/20
Ins(1,4,5)P3 (SCHEMBL4321735)	1.00	9/20
Ins(1,4,5)P3 (SCHEMBL4871682)	1.00	9/20
Ins(1,4,5)P3 (SCHEMBL4874594)	1.00	9/20
SCHEMBL1569348	0.86	9/20
SCHEMBL2724650	0.81	9/20
SCHEMBL5184816	0.77	9/20
SCHEMBL4343591	0.74	9/20
SCHEMBL4343592	0.74	9/20
SCHEMBL5056860	0.68	9/20
SCHEMBL5176539	0.65	9/20
SCHEMBL1929610	0.61	9/20
SCHEMBL5417857	0.61	9/20
Phytic Acid (SCHEMBL1172887)	0.54	9/20
Atrinositol (SCHEMBL134177)	1.00	8/20
Atrinositol (SCHEMBL180074)	1.00	8/20

Clinical trials — most relevant to ITPR3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Myo-inositol for the Management of Poor Ovarian Responders: A Prospective Randomized Controlled Trial	PHASE2/PHASE3	UNKNOWN
Role of Intralipid in Management of Organophosphorus Poisoning	PHASE2/PHASE3	WITHDRAWN
Can Calcium Ionophore Application Enhance the ICSI Outcomes in Severe Male Factor Infertility?	PHASE2/PHASE3	UNKNOWN
Next Generation ORS: Comparing ORS With Calcium vs Standard ORS in Reducing Severity of Acute Watery Diarrhea	PHASE2/PHASE3	COMPLETED
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction	PHASE2	ACTIVE_NOT_RECRUITING
Calcium Channel Blockade in Primary Aldosteronism	PHASE2	COMPLETED
A Phase I/II, First-In-Human Trial to Evaluate the Safety, Tolerability, and Pharmacokinetic Activity to Prevent or Treat Neuropsychiatric Symptoms in Pediatric Subjects With Timothy Syndrome	PHASE1/PHASE2	NOT_YET_RECRUITING
EDTA Eye Drops Compared to Abreva for Herpes Simplex Virus Eruptions	PHASE2	COMPLETED
Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma	PHASE2	RECRUITING
PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A	EARLY_PHASE1	COMPLETED
Early Detection of Cardiomyopathy by Speckle Echo, High Sensitive Troponin and Cardiac Ryanodine Receptors	nan	UNKNOWN
The Study Aims to Investigate the Effects of Oral Inositols on Insulin-resistance in Children With Obesity.	nan	UNKNOWN
Study of the Pathophysiological Mechanisms Involved in Bleeding Events	nan	COMPLETED
The Energetic Origin of Neurodegeneration in MS	nan	COMPLETED
Identifying Genetic Causes of IC/BPS	nan	RECRUITING
Molecular Markers of Human Sperm Function	nan	WITHDRAWN
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
An Epidemiological Study of Subjects With Immune Thrombocytopenic Purpura to Evaluate the Relationship Between Platelet Counts, Endogenous Thrombopoietin Levels, Endogenous Anti-Thrombopoietin Antibodies, and Selected Autoimmune Markers	nan	COMPLETED
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis	nan	UNKNOWN
Impact of Seasonal Malaria Chemoprevention on Immunity Against Malaria Among Children in Northern Benin	nan	COMPLETED
The Incidence of Hypocalcemia in Pregnant Women at Siriraj Hospital	nan	UNKNOWN
Evaluation of A Clinical Diagnostic Test for CRDS	nan	RECRUITING
Intra-cortical Inhibition and Cognitive Deficits in Schizophrenia	nan	UNKNOWN
Regulation of Vitamin D Receptor (VDR),Calcium Sensing Receptor (CaSR), Cyclin D1,Ki67 and Proliferating Cell Nuclear Antigen (PCNA) in Primary Hyperparathyroidism	nan	UNKNOWN
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
Myoinositol Treatment and Asprosin Levels in PCOS	nan	COMPLETED
Metabotropic Receptors For Glutamate Type 3 In Parkinson's	nan	UNKNOWN
Evaluation of Plasma Sphingosine-1-Phosphate as A Diagnostic and Prognostic Biomarkers of Community-Acquired Pneumonia	nan	UNKNOWN
Prevalence and Risk Factors of Nephrocalcinosis in Children at Sohag University Hospital	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ITPR3 binder may also engage these)

Protein	Name	Similarity
Q8WN95	—	1.000	Q8WN95 →
P70227	—	1.000	P70227 →
ITPR2	Inositol 1,4,5-trisphosphate-gated calcium ch	1.000	landscape →
Q8WSR4	—	1.000	Q8WSR4 →
Q63269	—	1.000	Q63269 →
P29994	—	1.000	P29994 →
Q9Z329	—	1.000	Q9Z329 →
ITPR1	Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1	1.000	landscape →
Q8WN96	—	1.000	Q8WN96 →
P11881	—	1.000	P11881 →
Q9TU34	—	1.000	Q9TU34 →
P29995	—	0.998	P29995 →
P29993	—	0.994	P29993 →
Q24498	—	0.992	Q24498 →
DNAJC13	DnaJ homolog subfamily C member 13	0.991	landscape →
B1AY13	—	0.985	B1AY13 →
O94915	—	0.985	O94915 →
Q9Y0A1	—	0.984	Q9Y0A1 →
USP24	Ubiquitin carboxyl-terminal hydrolase 24	0.984	landscape →
Q6P5D8	—	0.982	Q6P5D8 →
Q5ZL91	—	0.982	Q5ZL91 →
A6N6J5	—	0.982	A6N6J5 →
Q21029	—	0.981	Q21029 →
F4IDS7	—	0.981	F4IDS7 →
PDS5A	Sister chromatid cohesion protein PDS5 homolog A	0.981	landscape →
O35099	—	0.981	O35099 →
MAP3K5	Mitogen-activated protein kinase kinase kinase 5	0.981	landscape →
A1L1F4	—	0.981	A1L1F4 →
Q9NVH2	—	0.981	Q9NVH2 →
Q6DDI6	—	0.980	Q6DDI6 →