SCHEMBL25328877

SCHEMBL25328877

Cn1ccnc1-c1nc2ccc(C(F)(F)F)cn2c1Cl

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 8/20 0.44
ALDH1A1 P00352 3/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
SLC2A1 P11166 1/20 0.38
MCL1 Q07820 1/20 0.37
GABRD O14764 1/20 0.36
GABRB1 P18505 1/20 0.36
GABRA4 P48169 1/20 0.36
KDM4E B2RXH2 3/20 0.36
RXFP1 Q9HBX9 2/20 0.36
CYP11B1 P15538 1/20 0.36
CYP11B2 P19099 1/20 0.36
USP7 Q93009 1/20 0.36
HSD17B10 Q99714 1/20 0.34
NR1H4 Q96RI1 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25325213 0.80 TRPA1 (0.40) TRPA1ALDH1A1SMN1; SMN2SLC2A1KDM4E
SCHEMBL29556695 0.73 NPC1 (0.52) ALDH1A1SMN1; SMN2SLC2A1MCL1KDM4E
SCHEMBL29181625 0.72 SMN1; SMN2 (0.48) TRPA1ALDH1A1SMN1; SMN2SLC2A1GABRD
SCHEMBL17110772 0.70 NPC1 (0.49) ALDH1A1SMN1; SMN2MCL1KDM4ERXFP1
SCHEMBL16813077 0.70 TRPA1 (0.44) TRPA1ALDH1A1SMN1; SMN2SLC2A1GABRD
SCHEMBL22519104 0.69 ALDH1A1 (0.49) TRPA1ALDH1A1SMN1; SMN2SLC2A1GABRD
SCHEMBL25326583 0.69 SMN1; SMN2 (0.46) TRPA1ALDH1A1SMN1; SMN2SLC2A1GABRD
SCHEMBL7845612 0.69 KIF11 (0.47) MCL1KDM4E
SCHEMBL21182252 0.68 TRPA1 (0.46) TRPA1ALDH1A1SMN1; SMN2SLC2A1GABRD
SCHEMBL31312490 0.67 ALDH1A1 (0.43) TRPA1ALDH1A1SMN1; SMN2SLC2A1GABRD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230357232-A1 IMIDAZO[1,2-A]PYRIDINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2023-11-09 US disclosed
US-20230357232-A1 IMIDAZO[1,2-A]PYRIDINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2023-11-09 US disclosed
EP-4219491-A1 IMIDAZO[1,2-A]PYRIDINE COMPOUND AND PEST CONTROL AGENT Nippon Soda Co., Ltd. (JP) 2023-08-02 EP disclosed
WO-2022065235-A1 IMIDAZO[1,2-A]PYRIDINE COMPOUND AND PEST CONTROL AGENT 日本曹達株式会社 2022-03-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230357232-A1 IMIDAZO[1,2-A]PYRIDINE COMPOUND AND PEST CONTROL AGENT CTRL, CBR3, ITPR3 TRPA1 490/4885ALDH1A1 2175/4885SMN1; SMN2 730/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.