SCHEMBL25327414

C[C@@H]1CN(C(=O)C(=O)OCC(F)(F)F)[C@@H](c2ccccc2)CN1C(=O)C(C)(C)CN(C)C.C[C@@H]1CN[C@@H](c2ccccc2)CN1C(=O)C(C)(C)CN(C)C

nearest known ligand 0.36

Predicted protein targets (top 6)

	gene	UniProt	supporting neighbours	confidence
▸	PDK1	Q15118	2/20	0.34

▸	PDK2	Q15119	2/20	0.34

▸	PDK3	Q15120	2/20	0.34

▸	PDK4	Q16654	2/20	0.34

▸	RIPK1	Q13546	2/20	0.32

▸	FABP7	O15540	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL25323657	0.92	PDK1 (0.39)	PDK1PDK2PDK3PDK4RIPK1
SCHEMBL25325264	0.91	RIPK1 (0.38)	PDK1PDK2PDK3PDK4RIPK1
SCHEMBL25326936	0.89	PDK1 (0.37)	PDK1PDK2PDK3PDK4RIPK1
SCHEMBL25327967	0.83	RIPK1 (0.41)	PDK1PDK2PDK3PDK4RIPK1
SCHEMBL30523075	0.83	NR1H2 (0.38)	PDK1PDK2PDK3PDK4RIPK1
SCHEMBL25326422	0.81	RIPK1 (0.45)	PDK1PDK2PDK3PDK4RIPK1
SCHEMBL25327440	0.81	RIPK1 (0.33)	PDK1PDK2PDK3PDK4RIPK1
SCHEMBL25327351	0.80	RIPK1 (0.38)	PDK1PDK2PDK3PDK4RIPK1
SCHEMBL25916336	0.79	PDK2 (0.33)	PDK1PDK2PDK3PDK4
SCHEMBL25327418	0.79	FABP7 (0.32)	PDK1PDK2PDK3PDK4RIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2023146991-A1	COMPOUNDS AND METHODS OF USE	TANGO THERAPEUTICS, INC. (US)	2023-08-03	—	—	WO	disclosed