Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15834222 | 0.88 | TDP1 (0.72) | TDP1L3MBTL1KDM4EPOLBCTDSP1 | |
| SCHEMBL25329111 | 0.87 | POLB (0.58) | TDP1L3MBTL1KDM4EPOLBCTDSP1 | |
| SCHEMBL30515532 | 0.84 | ALDH1A1 (0.41) | TDP1L3MBTL1KDM4EPOLBCTDSP1 | |
| SCHEMBL6217472 | 0.84 | ALDH1A1 (0.41) | TDP1L3MBTL1KDM4EPOLBCTDSP1 | |
| SCHEMBL1554733 | 0.83 | KDM4E (0.61) | TDP1L3MBTL1KDM4EPOLBCTDSP1 | |
| SCHEMBL19877768 | 0.82 | POLB (0.59) | TDP1L3MBTL1KDM4EPOLBCTDSP1 | |
| SCHEMBL1553814 | 0.80 | TDP1 (0.56) | TDP1L3MBTL1KDM4EPOLBCTDSP1 | |
| SCHEMBL31143111 | 0.79 | TDP1 (0.51) | TDP1L3MBTL1KDM4EPOLBCTDSP1 | |
| SCHEMBL8161303 | 0.79 | GPR35 (0.42) | TDP1L3MBTL1KDM4EPOLBCTDSP1 | |
| SCHEMBL29792549 | 0.79 | LMNA (0.53) | TDP1L3MBTL1KDM4EHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023143135-A1 | QUINAZOLINE DERIVATIVE AND USE THEREOF | 赛诺哈勃药业（成都）有限公司 | 2023-08-03 | — | — | WO | disclosed |
| CN-116514728-A | Quinazoline derivative and application thereof | 赛诺哈勃药业（成都）有限公司 | 2023-08-01 | — | — | CN | disclosed |