Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.40 |
| ▸ | FPR1 | P21462 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.35 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.35 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25330144 | 0.88 | TEAD1 (0.46) | MTNR1AMTNR1BGRM2FPR1FPR2 | |
| SCHEMBL30767979 | 0.87 | EPHX2 (0.40) | MTNR1AMTNR1BGRM2FPR1FPR2 | |
| SCHEMBL25330046 | 0.84 | MTNR1A (0.59) | MTNR1AMTNR1BFPR1FPR2NOTUM | |
| SCHEMBL25331389 | 0.80 | MTNR1A (0.42) | MTNR1AMTNR1BHDAC1NOTUMSRPK1 | |
| SCHEMBL25331132 | 0.79 | TEAD1 (0.48) | MTNR1AMTNR1BGRM2FPR1FPR2 | |
| SCHEMBL25329168 | 0.79 | GRM2 (0.36) | MTNR1AMTNR1BGRM2FPR1FPR2 | |
| SCHEMBL25379854 | 0.77 | FPR1 (0.41) | GRM2FPR1FPR2TRPM8HDAC1 | |
| SCHEMBL29073321 | 0.77 | GRM2 (0.37) | GRM2FPR1FPR2TRPM8HDAC1 | |
| SCHEMBL25379936 | 0.76 | MTNR1A (0.46) | MTNR1AMTNR1BFPR1FPR2TRPM8 | |
| SCHEMBL25332512 | 0.75 | NOTUM (0.36) | MTNR1AMTNR1BGRM2FPR1FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025856-A1 | 1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AS INHIBITORS OF THE YAP/TAZ-TEAD ACTIVATION FOR TREATING CANCER | CISTIM LEUVEN VZW (BE) | 2024-01-25 | — | — | US | disclosed |
| EP-4222143-A1 | 1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AS INHIBITORS OF THE YAP/TAZ-TEAD ACTIVATION FOR TREATING CANCER | Katholieke Universiteit Leuven (BE) | 2023-08-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025856-A1 | 1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AS INHIBITORS OF THE YAP/TAZ-TEAD ACTIVATION FOR TREATING CANCER | YAP1, TEAD2, TEAD1 | MTNR1A 1460/4885MTNR1B 1468/4885GRM2 4221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.