Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25331977 | 1.00 | BLM (0.45) | BLMCYP2D6CYP2C19HIF1ACETP | |
| SCHEMBL25332274 | 1.00 | BLM (0.45) | BLMCYP2D6CYP2C19HIF1ACETP | |
| SCHEMBL21580243 | 0.81 | CYP2C19 (0.51) | BLMCYP2D6CYP2C19HIF1ACHRM2 | |
| SCHEMBL17582871 | 0.81 | CYP2C19 (0.51) | BLMCYP2D6CYP2C19HIF1ACHRM2 | |
| SCHEMBL17582794 | 0.81 | CYP2C19 (0.51) | BLMCYP2D6CYP2C19HIF1ACHRM2 | |
| SCHEMBL30001155 | 0.80 | SMN1; SMN2 (0.38) | BLMCYP2D6CETPSMN1; SMN2L3MBTL1 | |
| SCHEMBL745452 | 0.76 | CYP2C19 (0.56) | BLMCYP2D6CYP2C19HIF1ACETP | |
| SCHEMBL5929556 | 0.76 | L3MBTL1 (0.52) | BLMCYP2D6CYP2C19HIF1ACETP | |
| SCHEMBL17743682 | 0.76 | CYP2C19 (0.47) | BLMCYP2D6CYP2C19HIF1ACETP | |
| SCHEMBL6570728 | 0.76 | L3MBTL1 (0.52) | BLMCYP2D6CYP2C19HIF1ACETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250066351-A1 | PYRAZOLO[1,5-A]PYRIDIN-2,3-YL AMIDES AS KV7 CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD (US) | 2025-02-27 | — | — | US | disclosed |
| EP-4460501-A1 | PYRAZOLO[1,5-A]PYRIDIN-2,3-YL AMIDES AS KV7 CHANNEL ACTIVATORS | Biohaven Therapeutics Ltd. (US) | 2024-11-13 | — | — | EP | disclosed |
| CN-118510777-A | Pyrazolo [1,5-a ] pyridin-2, 3-ylamides as Kv7 channel activators | 拜奥海芬治疗学有限公司 | 2024-08-16 | — | — | CN | disclosed |
| WO-2023133256-A1 | PYRAZOLO[1,5-A]PYRIDIN-2,3-YL AMIDES AS KV7 CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD. (US) | 2023-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250066351-A1 | PYRAZOLO[1,5-A]PYRIDIN-2,3-YL AMIDES AS KV7 CHANNEL ACTIVATORS | KCNA7, KCNK17, KCNA1 | BLM 2862/4885CYP2D6 592/4885CYP2C19 596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.