Tetraxetan

Tetraxetan

SCHEMBL2533646

O=C(O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1.[Fe].[NaH]

nearest known ligand 0.88

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 2/20 0.58
SLC6A9 P48067 1/20 0.44
S1PR1 P21453 1/20 0.39
ALDH1A1 P00352 4/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
STAT6 P42226 1/20 0.38
GAA P10253 1/20 0.37
KDM4E B2RXH2 2/20 0.36
MAPT P10636 1/20 0.35
CYP1A2 P05177 1/20 0.34
MAPK1 P28482 1/20 0.34
ALOX15 P16050 1/20 0.34
TSHR P16473 1/20 0.34
ITGB3 P05106 1/20 0.34
ITGA2B P08514 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetraxetan SCHEMBL3791387 0.97 HSD17B10 (0.61) HSD17B10SLC6A9S1PR1ALDH1A1SMN1; SMN2
Tetraxetan SCHEMBL1953760 0.94 HSD17B10 (0.58) HSD17B10SLC6A9S1PR1ALDH1A1SMN1; SMN2
SCHEMBL321989 0.94 HSD17B10 (0.64) HSD17B10SLC6A9S1PR1ALDH1A1SMN1; SMN2
Tetraxetan SCHEMBL2635294 0.94 HSD17B10 (0.64) HSD17B10SLC6A9S1PR1ALDH1A1SMN1; SMN2
SCHEMBL6744121 0.94 HSD17B10 (0.64) HSD17B10SLC6A9S1PR1ALDH1A1SMN1; SMN2
Tetraxetan SCHEMBL2017956 0.94 HSD17B10 (0.64) HSD17B10SLC6A9S1PR1ALDH1A1SMN1; SMN2
SCHEMBL6848102 0.94 HSD17B10 (0.64) HSD17B10SLC6A9S1PR1ALDH1A1SMN1; SMN2
Tetraxetan SCHEMBL18018 0.94 HSD17B10 (0.64) HSD17B10SLC6A9S1PR1ALDH1A1SMN1; SMN2
SCHEMBL173508 0.94 HSD17B10 (0.64) HSD17B10SLC6A9S1PR1ALDH1A1SMN1; SMN2
SCHEMBL3660521 0.94

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2561334-A1 PRODUCTS AND METHODS FOR TISSUE PRESERVATION Genvault Corporation (US) 2013-02-27 EP disclosed
WO-2011130280-A1 PRODUCTS AND METHODS FOR TISSUE PRESERVATION GENVAULT CORPORATION (US) 2011-10-20 WO disclosed
US-20110256530-A1 PRODUCTS AND METHODS FOR TISSUE PRESERVATION GENVAULT CORPORATION (US) 2011-10-20 US disclosed