Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 1.00 |
| ▸ | TSHR | P16473 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.83 |
| ▸ | MEN1 | O00255 | 11/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.83 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.83 |
| ▸ | LMNA | P02545 | 6/20 | 0.82 |
| ▸ | HPGD | P15428 | 2/20 | 0.82 |
| ▸ | GAA | P10253 | 2/20 | 0.80 |
| ▸ | HTT | P42858 | 1/20 | 0.80 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2527962 | 0.90 | MAPT (1.00) | MAPTTSHRMAPK1TP53HSD17B10 | |
| SCHEMBL2534117 | 0.89 | KMT2A (1.00) | MAPTTSHRMAPK1TP53HSD17B10 | |
| SCHEMBL2535208 | 0.85 | MAPT (1.00) | MAPTTSHRMAPK1TP53HSD17B10 | |
| SCHEMBL24711194 | 0.81 | KMT2A (0.71) | MAPTTSHRMAPK1TP53HSD17B10 | |
| SCHEMBL27628011 | 0.80 | MAPT (0.73) | MAPTTSHRMAPK1TP53HSD17B10 | |
| SCHEMBL6632563 | 0.76 | RAB9A (0.68) | MAPTTSHRMAPK1KMT2AMEN1 | |
| SCHEMBL6632076 | 0.76 | NPC1 (1.00) | MAPTTSHRMAPK1KMT2AMEN1 | |
| SCHEMBL6633899 | 0.75 | PTPN2 (0.75) | MAPTTP53KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL23011774 | 0.75 | ALDH1A1 (0.84) | MAPTTSHRMAPK1KMT2AMEN1 | |
| SCHEMBL27608843 | 0.73 | MAOB (0.68) | MAPTTSHRMAPK1TP53HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110257182-A1 | Novel amido derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors | BOLEA CHRISTELLE | 2011-10-20 | — | — | US | claimed |
| US-20110257182-A1 | Novel amido derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors | BOLEA CHRISTELLE | 2011-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257182-A1 | Novel amido derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors | GRM4, GRM1, GRM3 | MAPT 1940/4885TSHR 390/4885MAPK1 1255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.