Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EZH2 | Q15910 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29457507 | 0.75 | SYK (0.45) | SYKMAP4K4SMN1; SMN2GAAPOLB | |
| SCHEMBL25344922 | 0.72 | BCAT2 (0.53) | SYKMAP4K4SMN1; SMN2GAAPOLB | |
| SCHEMBL27211402 | 0.70 | SYK (0.43) | SYKMAP4K4SMN1; SMN2GAAPOLB | |
| SCHEMBL30473670 | 0.70 | SYK (0.43) | SYKMAP4K4SMN1; SMN2GAAPOLB | |
| SCHEMBL25342784 | 0.69 | MAP4K4 (0.46) | SYKMAP4K4SMN1; SMN2GAAPOLB | |
| SCHEMBL13875913 | 0.68 | NPC1 (0.43) | MAP4K4SMN1; SMN2GAAPOLBNPC1 | |
| SCHEMBL25345885 | 0.68 | PARP15 (0.40) | — | |
| SCHEMBL13875996 | 0.65 | PIN1 (0.41) | SYKMAP4K4SMN1; SMN2GAAPOLB | |
| SCHEMBL28866136 | 0.65 | GAA (0.49) | MAP4K4SMN1; SMN2GAAPOLBNPC1 | |
| SCHEMBL7689351 | 0.65 | CTNNB1 (0.57) | SMN1; SMN2GAAPOLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225746-A1 | MRGX2 ANTAGONISTS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2023-08-16 | — | — | EP | disclosed |