Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KRAS | P01116 | 5/20 | 0.35 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | MPL | P40238 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25344261 | 0.76 | CRHR1 (0.31) | MPL | |
| SCHEMBL19968786 | 0.74 | BACE1 (0.44) | KDM4EALDH1A1KMT2AKRASBACE1 | |
| SCHEMBL29937121 | 0.71 | NOS3 (0.52) | KDM4EALDH1A1KMT2ABACE1NOS3 | |
| SCHEMBL14108794 | 0.71 | NOS3 (0.52) | KDM4EALDH1A1KMT2ABACE1NOS3 | |
| SCHEMBL19968792 | 0.71 | MPL (0.44) | KDM4EALDH1A1KMT2AKRASBACE1 | |
| SCHEMBL29464972 | 0.71 | ABL1 (0.44) | KDM4EALDH1A1KMT2AKRASBACE1 | |
| SCHEMBL19927757 | 0.71 | ABL1 (0.44) | KDM4EALDH1A1KMT2AKRASBACE1 | |
| SCHEMBL25203566 | 0.70 | AURKA (0.39) | KDM4E | |
| SCHEMBL21412576 | 0.70 | PDE3B (0.38) | KMT2ABACE1 | |
| SCHEMBL24360872 | 0.68 | BACE1 (0.48) | KDM4EALDH1A1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4476204-A1 | COMPOUNDS HAVING A T-STRUCTURE FORMED BY AT LEAST FOUR CYCLES FOR USE IN THE TREATMENT OF CANCER AND OTHER INDICATIONS | Theras, Inc. (US) | 2024-12-18 | — | — | EP | disclosed |
| WO-2023154282-A1 | COMPOUNDS HAVING A T-STRUCTURE FORMED BY AT LEAST FOUR CYCLES FOR USE IN THE TREATMENT OF CANCER AND OTHER INDICATIONS | THERAS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |