Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 5/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 2/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 3/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL28458351 | 0.87 | ALDH1A1 (0.56) | MEN1KMT2ATDP1ALDH1A1MAPT | |
| Benzene SCHEMBL28468265 | 0.87 | ALDH1A1 (0.56) | MEN1KMT2ATDP1ALDH1A1MAPT | |
| SCHEMBL125083 | 0.87 | APP (0.59) | ALDH1A1MAPTTGM2APPFBP1 | |
| SCHEMBL28587124 | 0.87 | APP (0.59) | ALDH1A1MAPTTGM2APPFBP1 | |
| Water SCHEMBL20553645 | 0.85 | APP (0.57) | KDM4EALDH1A1MAPTTGM2APP | |
| Ethylene SCHEMBL28539188 | 0.85 | APP (0.57) | ALDH1A1MAPTTGM2APPFBP1 | |
| Hydrogen Sulfide SCHEMBL28134384 | 0.85 | APP (0.57) | ALDH1A1MAPTTGM2APPFBP1 | |
| SCHEMBL28509790 | 0.82 | SRD5A2 (0.62) | TDP1ALDH1A1POLBGAAMAPT | |
| SCHEMBL42325 | 0.81 | MEN1 (0.71) | MEN1KMT2APOLBMAPTMAOB | |
| SCHEMBL277169 | 0.81 | MEN1 (0.71) | MEN1KMT2APOLBMAPTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023151118-A1 | STYRENE-MALEIC ACID COPOLYMERIZED MACROMOLECULAR REACTIVE DYE AND PREPARATION METHOD THEREFOR | 大连理工大学 | 2023-08-17 | — | — | WO | claimed |
| CN-114437278-A | Styrene maleic acid copolymerization macromolecular reactive dye and preparation method thereof | 大连理工大学 | 2022-05-06 | — | — | CN | claimed |
| WO-2023151118-A1 | STYRENE-MALEIC ACID COPOLYMERIZED MACROMOLECULAR REACTIVE DYE AND PREPARATION METHOD THEREFOR | 大连理工大学 | 2023-08-17 | — | — | WO | disclosed |
| CN-114437278-A | Styrene maleic acid copolymerization macromolecular reactive dye and preparation method thereof | 大连理工大学 | 2022-05-06 | — | — | CN | disclosed |