Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 known ✓ | P29474 | 3/20 | 0.44 |
| ▸ | NOS1 known ✓ | P29475 | 3/20 | 0.44 |
| ▸ | NOS2 known ✓ | P35228 | 3/20 | 0.44 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | KYNU | Q16719 | 2/20 | 0.39 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288832 | 0.79 | SLC7A5 (0.60) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL288377 | 0.79 | SLC7A5 (0.60) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL385780 | 0.79 | SLC7A5 (0.60) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL29701247 | 0.79 | SLC7A5 (0.60) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL5703686 | 0.78 | ESR1 (0.39) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL28797485 | 0.78 | APAF1 (0.51) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Carbamic Acid SCHEMBL7552214 | 0.77 | HTR2A (0.43) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL16397405 | 0.77 | SLC7A5 (0.73) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL16397404 | 0.77 | SLC7A5 (0.73) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Acetic Acid SCHEMBL9403713 | 0.77 | AKR1B1 (0.55) | PTGS1FDPSOPRK1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2561334-A1 | PRODUCTS AND METHODS FOR TISSUE PRESERVATION | Genvault Corporation (US) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011130280-A1 | PRODUCTS AND METHODS FOR TISSUE PRESERVATION | GENVAULT CORPORATION (US) | 2011-10-20 | — | — | WO | disclosed |
| US-20110256530-A1 | PRODUCTS AND METHODS FOR TISSUE PRESERVATION | GENVAULT CORPORATION (US) | 2011-10-20 | — | — | US | disclosed |