SCHEMBL288377

SCHEMBL288377

Nc1ccccc1C[C@H](N)C(=O)O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 3/20 0.60
PKM P14618 2/20 0.60
ALPI P09923 1/20 0.60
PTGS1 P23219 1/20 0.60
XIAP P98170 1/20 0.60
NOS3 P29474 3/20 0.58
NOS1 P29475 3/20 0.58
NOS2 P35228 3/20 0.58
MAPT P10636 3/20 0.53
KDM4E B2RXH2 2/20 0.53
MEN1 O00255 2/20 0.53
LMNA P02545 2/20 0.53
BLM P54132 2/20 0.53
PMP22 Q01453 2/20 0.53
KMT2A Q03164 2/20 0.53
HIF1A Q16665 2/20 0.53
MPO P05164 1/20 0.53
TSHR P16473 1/20 0.53
KYNU Q16719 2/20 0.51
USP2 O75604 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29701247 1.00 SLC7A5 (0.60) SLC7A5PKMALPIPTGS1XIAP
SCHEMBL385780 1.00 SLC7A5 (0.60) SLC7A5PKMALPIPTGS1XIAP
SCHEMBL288832 1.00 SLC7A5 (0.60) SLC7A5PKMALPIPTGS1XIAP
Phenylalanine SCHEMBL16397405 0.93 SLC7A5 (0.73) SLC7A5PKMALPIPTGS1XIAP
Dl-Phenylalanine SCHEMBL16397404 0.93 SLC7A5 (0.73) SLC7A5PKMALPIPTGS1XIAP
SCHEMBL13971424 0.88 SLC7A5 (0.69) SLC7A5PKMALPIPTGS1XIAP
SCHEMBL9164980 0.88 SLC7A5 (0.69) SLC7A5PKMALPIPTGS1XIAP
Hydrochloric Acid SCHEMBL9169793 0.86 SLC7A5 (0.67) SLC7A5PKMALPIPTGS1XIAP
SCHEMBL13703210 0.85 PKM (0.52) SLC7A5PKMALPIPTGS1XIAP
SCHEMBL10886402 0.83 NOS3 (0.41) SLC7A5PKMALPIPTGS1XIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 400 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12577575-B2 Methods and compositions for promoting non-natural amino acid-containing protein production AMBRX, INC. (US) 2026-03-17 US claimed
US-12404512-B2 Method for optimizing antibody expression AMBRX, INC. (US) 2025-09-02 US claimed
EP-3788149-B1 A METHOD FOR OPTIMIZING ANTIBODY EXPRESSION AMBRX INC (US) 2025-08-27 EP claimed
US-12377294-B2 Anti-CD3 antibody folate bioconjugates and their uses AMBRX, INC. (US) 2025-08-05 US claimed
CN-119455004-A Compositions, methods and uses comprising antibody-TLR agonist conjugates AMBRX公司 2025-02-18 CN claimed
CN-119455003-A Compositions, methods and uses comprising antibody-TLR agonist conjugates AMBRX公司 2025-02-18 CN claimed
EP-4461318-A2 NOVEL ANTI-PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) ANTIBODY DRUG CONJUGATES Ambrx, Inc. (US) 2024-11-13 EP claimed
US-20240350835-A1 HUMANIZED ANTI-PROSTATE -SPECIFIC MEMBRANE ANTIGEN (PSMA) ANTIBODY DRUG CONJUGATES AMBRX, INC. (US) 2024-10-24 US claimed
WO-2024178360-A2 AURISTATIN ANALOGS AND ANTIBODY CONJUGATES THEREOF AMBRX, INC. (US) 2024-08-29 WO claimed
US-12059473-B2 Humanized anti-prostate -specific membrane antigen (PSMA) antibody drug conjugates AMBRX, INC. (US) 2024-08-13 US claimed
EP-2836485-A1 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS Polyphor Ag (CH) 2015-02-18 EP claimed
EP-2462147-B1 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS POLYPHOR AG (CH) 2014-11-12 EP claimed
WO-2013139697-A1 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS POLYPHOR AG (CH) 2013-09-26 WO claimed
US-20120270881-A1 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS POLYPHOR AG (CH) 2012-10-25 US claimed
EP-2499148-A2 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS Polyphor Ag (CH) 2012-09-19 EP claimed
US-20120202821-A1 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS POLYPHOR AG (CH) 2012-08-09 US claimed
WO-2011014973-A2 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS POLYPHOR AG (CH) 2011-02-10 WO claimed
EP-1991572-A2 PEPTIDES THAT BLOCK THE BINDING OF IGG TO FCRN SYNTONIX PHARMACEUTICALS, INC. (US) 2008-11-19 EP claimed
US-20070254831-A1 PEPTIDES THAT BLOCK THE BINDING OF IgG to FcRn BIOGEN HEMOPHILIA INC. 2007-11-01 US claimed
WO-2007098420-A2 PEPTIDES THAT BLOCK THE BINDING OF IGG TO FCRN SYNTONIX PHARMACEUTICALS, INC. (US) 2007-08-30 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120202821-A1 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS HTR2B, MC1R, HTR1A SLC7A5 1600/4885PKM 2553/4885ALPI 2014/4885
US-12059473-B2 Humanized anti-prostate -specific membrane antigen (PSMA) antibody drug conjugates FOLH1, KLK3, PSMA6 SLC7A5 1731/4885PKM 1370/4885ALPI 249/4885
US-12377294-B2 Anti-CD3 antibody folate bioconjugates and their uses FOLR2, FOLR1, CD2 SLC7A5 271/4885PKM 4371/4885ALPI 1217/4885
US-12577575-B2 Methods and compositions for promoting non-natural amino acid-containing protein production AARS1, NSUN3, UPF1 SLC7A5 136/4885PKM 2865/4885ALPI 2459/4885
US-20070254831-A1 PEPTIDES THAT BLOCK THE BINDING OF IgG to FcRn FCGRT, FCGR3B, FCGR1A SLC7A5 1904/4885PKM 4767/4885ALPI 3829/4885
US-20120270881-A1 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS KCNB1, KCNAB1, KCNMB1 SLC7A5 1849/4885PKM 1346/4885ALPI 2376/4885
US-20240350835-A1 HUMANIZED ANTI-PROSTATE -SPECIFIC MEMBRANE ANTIGEN (PSMA) ANTIBODY DRUG CONJUGATES FOLH1, KLK3, PSMA6 SLC7A5 1803/4885PKM 1423/4885ALPI 232/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.