Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.68 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | MC4R | P32245 | 2/20 | 0.45 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAN2A1 | Q16706 | 1/20 | 0.40 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 3/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3880578 | 1.00 | CTSD (0.68) | CTSDGBA1MC4RSLC18A3TRPM8 | |
| SCHEMBL2534991 | 1.00 | CTSD (0.68) | CTSDGBA1MC4RSLC18A3TRPM8 | |
| SCHEMBL2776534 | 0.86 | CTSD (0.55) | CTSDGBA1SLC18A3MEN1KMT2A | |
| SCHEMBL2776529 | 0.86 | CTSD (0.55) | CTSDGBA1SLC18A3MEN1KMT2A | |
| SCHEMBL2733318 | 0.84 | CTSD (0.64) | CTSDMC4RTRPM8MEN1KMT2A | |
| SCHEMBL16422495 | 0.83 | CTSD (0.54) | CTSDGBA1MC4RSLC18A3MEN1 | |
| SCHEMBL2495894 | 0.79 | SLC18A3 (0.60) | CTSDSLC18A3MEN1KMT2AAGER | |
| SCHEMBL4294468 | 0.78 | CTSD (0.60) | CTSDGBA1MC4RMEN1KMT2A | |
| SCHEMBL2421731 | 0.77 | CTSD (0.56) | CTSDMC4RMEN1KMT2AAGER | |
| SCHEMBL1467752 | 0.77 | CTSD (0.56) | CTSDSLC6A2SLC6A4SLC6A3AGER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044068-B2 | Aminopyrrolidine compound | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2011-10-25 | — | — | US | disclosed |
| EP-2010488-A2 | RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007117559-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |