Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.55 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776529 | 1.00 | CTSD (0.55) | CTSDGBA1SLC6A2SLC6A4KCNH2 | |
| SCHEMBL2534991 | 0.86 | CTSD (0.68) | CTSDGBA1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2534993 | 0.86 | CTSD (0.68) | CTSDGBA1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3880578 | 0.86 | CTSD (0.68) | CTSDGBA1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1976152 | 0.85 | CTSD (0.52) | CTSDSLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL6604042 | 0.85 | CTSD (0.52) | CTSDSLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL1976153 | 0.85 | CTSD (0.52) | CTSDSLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL15407540 | 0.85 | CTSD (0.52) | CTSDSLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL1976155 | 0.85 | CTSD (0.52) | CTSDSLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL1957769 | 0.85 | HSD11B1 (0.45) | CTSDSLC6A2SLC6A4KCNH2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507211-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2010065824-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-06-10 | — | — | WO | disclosed |