Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | SDCBP | O00560 | 1/20 | 0.32 |
| ▸ | SDC2 | P34741 | 1/20 | 0.32 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30623350 | 0.85 | ALDH1A1 (0.38) | MEN1KMT2A | |
| SCHEMBL26016812 | 0.85 | ALDH1A1 (0.38) | MEN1KMT2A | |
| SCHEMBL25357867 | 0.78 | HSD11B1 (0.40) | NOTUMHSD11B1AKR1B1MEN1KMT2A | |
| SCHEMBL30623425 | 0.72 | MEN1 (0.46) | MEN1KMT2A | |
| SCHEMBL2187569 | 0.72 | MEN1 (0.46) | MEN1KMT2A | |
| SCHEMBL17205567 | 0.70 | USP30 (0.48) | NOTUMMEN1KMT2A | |
| SCHEMBL25357142 | 0.70 | AKR1B1 (0.38) | NOTUMSIGMAR1AKR1B1MEN1KMT2A | |
| SCHEMBL13000679 | 0.70 | ALDH1A1 (0.40) | HSD11B1MEN1KMT2ADRD2 | |
| SCHEMBL13001434 | 0.70 | ALDH1A1 (0.40) | HSD11B1MEN1KMT2ADRD2 | |
| SCHEMBL25357843 | 0.68 | AVPR1A (0.33) | NOTUMAKR1B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |