Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY10 | Q96PN6 | 2/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.36 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25203400 | 0.83 | ADCY10 (0.40) | ADCY10SCN10ACASP1SCN1AKCNH2 | |
| SCHEMBL31330598 | 0.83 | ADCY10 (0.40) | ADCY10SCN10ACASP1SCN1AKCNH2 | |
| SCHEMBL17979068 | 0.81 | KDM4E (0.50) | CASP1KDM4EMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL31656690 | 0.81 | CFTR (0.41) | ADCY10SCN10ACASP1SCN1AKCNH2 | |
| SCHEMBL25360740 | 0.81 | CFTR (0.41) | ADCY10SCN10ACASP1SCN1AKCNH2 | |
| SCHEMBL30495159 | 0.80 | KDM4E (0.39) | CASP1KDM4EMAPTSMN1; SMN2USP2 | |
| SCHEMBL31392592 | 0.80 | LMNA (0.38) | CASP1MAPTALDH1A1S1PR2 | |
| SCHEMBL17979152 | 0.80 | KDM4E (0.39) | CASP1KDM4EMAPTSMN1; SMN2USP2 | |
| SCHEMBL31174353 | 0.79 | ALOX5AP (0.38) | ALDH1A1 | |
| SCHEMBL25235216 | 0.77 | CASP1 (0.40) | ADCY10CASP1KDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159155-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) AND USES THEREOF | PIVALENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |