SCHEMBL25362146

SCHEMBL25362146

Cc1ccc(F)c(S(=O)(=O)N2CCC3(CC2)CC(N2CCOCC2)CO3)c1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
KMT2A Q03164 4/20 0.42
TP53 P04637 1/20 0.42
ALDH1A1 P00352 2/20 0.42
SMN1; SMN2 Q16637 4/20 0.41
TSHR P16473 3/20 0.41
LMNA P02545 3/20 0.40
MAPK1 P28482 2/20 0.40
MEN1 O00255 2/20 0.40
MAPT P10636 2/20 0.40
HTT P42858 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.38
USP2 O75604 1/20 0.38
GAA P10253 1/20 0.38
POLB P06746 1/20 0.38
CNR1 P21554 1/20 0.37
BRD4 O60885 1/20 0.37
BRD3 Q15059 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25364405 0.90 NPC1 (0.58) NPC1RAB9AKMT2AALDH1A1SMN1; SMN2
SCHEMBL26027027 0.87 ALDH1A1 (0.45) KMT2AALDH1A1SMN1; SMN2TSHRLMNA
SCHEMBL26027009 0.85 NPC1 (0.43) NPC1RAB9AKMT2AALDH1A1SMN1; SMN2
SCHEMBL26025892 0.85 TSHR (0.38) NPC1RAB9AKMT2AALDH1A1SMN1; SMN2
SCHEMBL31553442 0.83 ALDH1A1 (0.48) NPC1KMT2AALDH1A1SMN1; SMN2MAPK1
SCHEMBL26028948 0.82 LMNA (0.36) NPC1RAB9AKMT2AALDH1A1TSHR
SCHEMBL25363147 0.80 EPHX2 (0.43) KMT2AALDH1A1SMN1; SMN2TSHRLMNA
SCHEMBL26028982 0.79 LMNA (0.36) KMT2AALDH1A1TSHRLMNAMAPK1
SCHEMBL26029034 0.79 HPGD (0.39) NPC1RAB9AKMT2AALDH1A1SMN1; SMN2
SCHEMBL26028993 0.79 HPGD (0.39) NPC1RAB9AKMT2AALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250152574-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF BIOGEN MA INC. 2025-05-15 US claimed
CN-119731156-A Emopanamide binding protein inhibitors and uses thereof 渤健马萨诸塞州股份有限公司 2025-03-28 CN claimed
EP-4479384-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF Biogen MA Inc. (US) 2024-12-25 EP claimed
WO-2023154499-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF BIOGEN MA INC. (US) 2023-08-17 WO claimed
US-20250152574-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF BIOGEN MA INC. 2025-05-15 US disclosed
CN-119731156-A Emopanamide binding protein inhibitors and uses thereof 渤健马萨诸塞州股份有限公司 2025-03-28 CN disclosed
EP-4479384-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF Biogen MA Inc. (US) 2024-12-25 EP disclosed
WO-2023154499-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF BIOGEN MA INC. (US) 2023-08-17 WO disclosed
WO-2023154499-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF BIOGEN MA INC. (US) 2023-08-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250152574-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF EBPL, EBP, CREBBP NPC1 1293/4885RAB9A 3939/4885KMT2A 4010/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.