Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B2 | P80365 | 11/20 | 0.84 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.84 |
| ▸ | MAPT | P10636 | 3/20 | 0.84 |
| ▸ | POLB | P06746 | 1/20 | 0.84 |
| ▸ | APEX1 | P27695 | 1/20 | 0.84 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.72 |
| ▸ | CES2 | O00748 | 3/20 | 0.72 |
| ▸ | CES1 | P23141 | 3/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.72 |
| ▸ | PRKCH | P24723 | 1/20 | 0.72 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.72 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.72 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721438 | 0.91 | HSD11B1 (1.00) | HSD11B2HSD11B1MAPTPOLBAPEX1 | |
| SCHEMBL11186596 | 0.91 | HSD11B1 (1.00) | HSD11B2HSD11B1MAPTPOLBAPEX1 | |
| SCHEMBL420853 | 0.91 | HSD11B1 (1.00) | HSD11B2HSD11B1MAPTPOLBAPEX1 | |
| SCHEMBL13056500 | 0.91 | HSD11B1 (1.00) | HSD11B2HSD11B1MAPTPOLBAPEX1 | |
| SCHEMBL11186600 | 0.91 | HSD11B1 (1.00) | HSD11B2HSD11B1MAPTPOLBAPEX1 | |
| SCHEMBL18348593 | 0.91 | HSD11B1 (1.00) | HSD11B2HSD11B1MAPTPOLBAPEX1 | |
| SCHEMBL420854 | 0.91 | HSD11B1 (1.00) | HSD11B2HSD11B1MAPTPOLBAPEX1 | |
| SCHEMBL1721435 | 0.91 | HSD11B1 (1.00) | HSD11B2HSD11B1MAPTPOLBAPEX1 | |
| SCHEMBL23407262 | 0.88 | HSD11B1 (0.80) | HSD11B2HSD11B1MAPTPOLBAPEX1 | |
| SCHEMBL625669 | 0.85 | HSD11B2 (0.81) | HSD11B2HSD11B1MAPTPOLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240209019-A1 | COMPOUNDS AND METHODS FOR TREATING HYPERKALEMIA | ARDELYX, INC. (US) | 2024-06-27 | — | — | US | disclosed |
| US-11858959-B2 | Glycyrrhetinic acid derivatives for use in treating hyperkalemia | ARDELYX, INC. (US) | 2024-01-02 | — | — | US | disclosed |
| EP-4234016-A2 | GLYCYRRHETINIC ACID DERIVATIVES FOR USE IN TREATING HYPERKALEMIA | Ardelyx, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240209019-A1 | COMPOUNDS AND METHODS FOR TREATING HYPERKALEMIA | REN, NHERF1, KCNJ11 | HSD11B2 111/4885HSD11B1 137/4885MAPT 3747/4885 |
| US-11858959-B2 | Glycyrrhetinic acid derivatives for use in treating hyperkalemia | HSD11B2, HSD11B1, NR3C2 | HSD11B2 1/4885HSD11B1 2/4885MAPT 3972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.