Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4514236 | 0.78 | TDP1 (0.48) | TDP1TSHRSMN1; SMN2PDE7AGPR35 | |
| SCHEMBL11791465 | 0.76 | TDP1 (0.43) | TDP1TSHRSMN1; SMN2PDE7AGPR35 | |
| SCHEMBL8975016 | 0.75 | TDP1 (0.46) | TDP1TSHRSMN1; SMN2PDE7AGPR35 | |
| SCHEMBL11794427 | 0.75 | TDP1 (0.46) | TDP1TSHRSMN1; SMN2PDE7AGPR35 | |
| SCHEMBL1431415 | 0.74 | CYP3A4 (0.33) | TSHR | |
| SCHEMBL28303063 | 0.72 | ALDH1A1 (0.46) | TDP1TSHRSMN1; SMN2PDE7AGPR35 | |
| SCHEMBL2103778 | 0.70 | TDP1 (0.50) | TDP1TSHRSMN1; SMN2PDE7AALDH1A1 | |
| SCHEMBL190550 | 0.69 | TDP1 (0.72) | TDP1TSHRSMN1; SMN2PDE7AGPR35 | |
| SCHEMBL18286925 | 0.69 | TDP1 (0.58) | TDP1TSHRSMN1; SMN2GPR35ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9438398 | 0.68 | TDP1 (0.69) | TDP1TSHRSMN1; SMN2PDE7AGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044047-B2 | 5-substituted benzoxazines | HOFFMAN-LA ROCHE INC. (US) | 2011-10-25 | — | — | US | disclosed |
| US-20100063042-A1 | 5-SUBSTITUTED BENZOXAZINES | HOFFMANN-LA ROCHE, INC. | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063042-A1 | 5-SUBSTITUTED BENZOXAZINES | HTR5A, NPY5R, GABRA5 | TDP1 1397/4885TSHR 682/4885SMN1; SMN2 1235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.