SCHEMBL25376586

SCHEMBL25376586

[N-]=[N+]=NCCOCCOCCNC(=O)Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O

nearest known ligand 0.59

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ MAP1LC3B Q9GZQ8 9/20 0.59
▸ STAT3 P40763 1/20 0.56
▸ CRBN Q96SW2 7/20 0.49
▸ CSNK1A1 P48729 3/20 0.47
▸ IKZF1 Q13422 2/20 0.47
▸ IKZF3 Q9UKT9 3/20 0.47
▸ GSPT1 P15170 2/20 0.47
▸ SALL4 Q9UJQ4 2/20 0.47
▸ BRD4 O60885 2/20 0.47
▸ TNF P01375 1/20 0.47
▸ IL1B P01584 1/20 0.47
▸ DDB1 Q16531 1/20 0.47
▸ HDAC3 O15379 1/20 0.46
▸ HDAC1 Q13547 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30550160 1.00 MAP1LC3B (0.59) MAP1LC3BSTAT3CRBNCSNK1A1IKZF1
SCHEMBL21792624 0.91 MAP1LC3B (0.66) MAP1LC3BCRBNCSNK1A1IKZF1IKZF3
SCHEMBL26200447 0.91 MAP1LC3B (0.60) MAP1LC3BSTAT3CRBNCSNK1A1IKZF1
SCHEMBL30891789 0.90 STAT3 (0.53) MAP1LC3BSTAT3CRBNBRD4
SCHEMBL30891811 0.90 STAT3 (0.53) MAP1LC3BSTAT3CRBNBRD4
SCHEMBL28668320 0.90 STAT3 (0.53) MAP1LC3BSTAT3CRBNCSNK1A1IKZF3
SCHEMBL25031848 0.89 MAP1LC3B (0.52) MAP1LC3BSTAT3CRBNCSNK1A1IKZF3
SCHEMBL23772670 0.89 MAP1LC3B (0.51) MAP1LC3BSTAT3CRBNIKZF1IKZF3
SCHEMBL23772439 0.89 MAP1LC3B (0.51) MAP1LC3BSTAT3CRBNIKZF1IKZF3
SCHEMBL23772825 0.89 MAP1LC3B (0.51) MAP1LC3BSTAT3CRBNIKZF1IKZF3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250163066-A1 PROTACs of MALT1 TEGID THERAPEUTICS, INC. 2025-05-22 — — US disclosed
WO-2023164175-A2 PROTACS OF MALT1 TEGID THERAPEUTICS, INC. (US) 2023-08-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250163066-A1 PROTACs of MALT1 MALT1, BCL3, BCL9 MAP1LC3B 115/4885STAT3 3600/4885CRBN 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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