Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GRN | P28799 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.41 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25376747 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAHPGDGRNSORT1 | |
| Hydrochloric Acid SCHEMBL29099900 | 0.99 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAHPGDGRNSORT1 | |
| Hydrochloric Acid SCHEMBL29099902 | 0.99 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAHPGDGRNSORT1 | |
| SCHEMBL25376436 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAHPGDGRNSORT1 | |
| SCHEMBL25376440 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAHPGDGRNSORT1 | |
| SCHEMBL25374512 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAHPGDGRNSORT1 | |
| SCHEMBL25374519 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAHPGDGRNSORT1 | |
| SCHEMBL25376152 | 0.78 | L3MBTL1 (0.34) | SMN1; SMN2LMNAHPGDGRNSORT1 | |
| SCHEMBL25376158 | 0.78 | L3MBTL1 (0.34) | SMN1; SMN2LMNAHPGDGRNSORT1 | |
| SCHEMBL3318854 | 0.75 | SMN1; SMN2 (0.60) | SMN1; SMN2LMNAHPGDGRNSORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4484426-A1 | PYRIMIDO AROMATIC RING COMPOUND AND USE THEREOF IN DRUG | Sunshine Lake Pharma Co., Ltd. (CN) | 2025-01-01 | — | — | EP | disclosed |
| CN-116693527-A | Pyrimido aromatic ring compounds and application thereof in medicines | 广东东阳光药业股份有限公司 | 2023-09-05 | — | — | CN | disclosed |
| WO-2023160527-A1 | PYRIMIDO AROMATIC RING COMPOUND AND USE THEREOF IN DRUG | 广东东阳光药业股份有限公司 | 2023-08-31 | — | — | WO | disclosed |
| US-9656949-B2 | Substituted carboxylic acid derivatives as aggrecanase inhibitors for the treatment of osteoarthritis | MERCK PATENT GMBH (DE) | 2017-05-23 | — | — | US | disclosed |