Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 5/20 | 0.49 |
| ▸ | LTA4H | P09960 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.46 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25940273 | 0.88 | LTA4H (0.62) | KDM1ALTA4HKDM4EPSMB1PSMB5 | |
| SCHEMBL12315758 | 0.87 | KDM4E (0.63) | KDM1ALTA4HKDM4EPSMB1PSMB5 | |
| SCHEMBL7400266 | 0.85 | GAA (0.62) | KDM1ALTA4HKDM4E | |
| SCHEMBL19025372 | 0.85 | KDM1A (0.56) | KDM1ADRD3LTA4HKDM4EDRD2 | |
| SCHEMBL25376183 | 0.81 | KDM1A (0.53) | KDM1ADRD3LTA4HDRD2 | |
| SCHEMBL28504764 | 0.81 | NPC1 (0.60) | KDM1ALTA4HKDM4EHRH3 | |
| SCHEMBL3713953 | 0.81 | POLB (0.66) | KDM4EHRH3 | |
| SCHEMBL5175644 | 0.78 | MEN1 (0.58) | KDM1ADRD3LTA4HDRD2 | |
| SCHEMBL25379894 | 0.78 | KDM4E (0.58) | KDM1ALTA4HKDM4E | |
| SCHEMBL25381009 | 0.78 | KDM4E (0.58) | KDM1ALTA4HKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4482832-A1 | 5-[7-(3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBONYL)-1,2,3,4 TETRAHYDROISOQUINOLIN-6-Y L]-1H-PYRROLE-3-CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS | Les Laboratoires Servier (FR) | 2025-01-01 | — | — | EP | disclosed |
| CN-119053587-A | 5- [7- (3, 4-Dihydro-1H-isoquinoline-2-carbonyl) -1,2,3,4 tetrahydroisoquinolin-6-yl ] -1H-pyrrole-3-carboxamide derivatives, pharmaceutical compositions containing same and use thereof as pro-apoptotic agents | 法国施维雅药厂 | 2024-11-29 | — | — | CN | disclosed |
| WO-2023161317-A1 | 5-[7-(3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBONYL)-1,2,3,4 TETRAHYDROISOQUINOLIN-6-Y L]-1H-PYRROLE-3-CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS | LES LABORATOIRES SERVIER (FR) | 2023-08-31 | — | — | WO | disclosed |