Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | KDM1A | O60341 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 8/20 | 0.52 |
| ▸ | MMP1 | P03956 | 2/20 | 0.50 |
| ▸ | MMP9 | P14780 | 2/20 | 0.50 |
| ▸ | MMP13 | P45452 | 2/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5174031 | 0.89 | MEN1 (0.57) | MEN1ALDH1A1LMNAKMT2AKDM1A | |
| SCHEMBL5175416 | 0.82 | LTA4H (0.50) | MEN1ALDH1A1LMNAKMT2AKDM1A | |
| SCHEMBL25940273 | 0.81 | LTA4H (0.62) | KDM1ALTA4H | |
| SCHEMBL6750008 | 0.81 | OPRL1 (0.64) | SIGMAR1 | |
| SCHEMBL12315758 | 0.80 | KDM4E (0.63) | KDM1ALTA4H | |
| SCHEMBL4688810 | 0.80 | MEN1 (0.62) | MEN1ALDH1A1LMNAKMT2ALTA4H | |
| SCHEMBL5175157 | 0.79 | MEN1 (0.56) | MEN1ALDH1A1LMNAKMT2ALTA4H | |
| Hydrochloric Acid SCHEMBL7406712 | 0.79 | MEN1 (0.61) | MEN1ALDH1A1LMNAKMT2ALTA4H | |
| SCHEMBL5175324 | 0.78 | KCNA5 (0.54) | MEN1ALDH1A1LMNAKMT2ALTA4H | |
| SCHEMBL25377857 | 0.78 | KDM1A (0.56) | KDM1ALTA4HDRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868605-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006105304-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | WO | disclosed |
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | LTA4H, LTB4R, LTC4S | MEN1 4858/4885ALDH1A1 1142/4885LMNA 2091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.